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1.发明授权Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia 有权用于治疗肥胖症，胰岛素相关疾病和高胆固醇血症的方法和组合物公开(公告)号：US07772195B2
公开(公告)日：2010-08-10
申请号：US11072151
申请日：2005-03-04
IPC分类号： A61K31/7048 , A61K31/57 , A61K31/353
CPC分类号： A61K31/353 , A61K31/57 , A61K31/7048
摘要： A method for the treatment of obesity, diabetes, high cholesterol and related diseases including hyperglycemia, lipid disorders, hyperglyceridemia, dyslipidemia and atherosclerosis in mammals using anthocyanins, anthocyanidins, ursolic acid and/or betulinic acid is described. Compositions adapted for these treatments are also described.
摘要翻译： 描述了使用花青素，花青素，熊果酸和/或桦木酸的哺乳动物中治疗肥胖症，糖尿病，高胆固醇和相关疾病的方法，包括高血糖症，脂质紊乱，高甘油三酯血症，血脂异常和动脉粥样硬化。 还描述了适于这些处理的组合物。
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2.发明申请METHODS AND COMPOSITIONS FOR THE TREATMENT OF OBESITY, INSULIN RELATED DISEASES AND HYPERCHOLESTEROLEMIA 审中-公开治疗肥胖，胰岛素相关疾病和高脂血症的方法和组合公开(公告)号：US20120283203A1
公开(公告)日：2012-11-08
申请号：US13460781
申请日：2012-04-30
IPC分类号： A61K31/7048 , A61P5/10 , A61P3/00 , A61K31/352 , A61P3/06
CPC分类号： A61K31/353 , A61K31/57 , A61K31/7048
摘要： A process of enhancing insulin excretion in a subject includes administering to the subject a polyphenol active ingredient. The polyphenol active ingredient is a purified cyanidin-3-glycoside alone or purified cyanidin alone. The pharmaceutically acceptable carrier is administered with the polyphenol active ingredient.
摘要翻译： 增加受试者胰岛素排泄的过程包括向受试者施用多酚活性成分。 多酚活性成分是纯化的花青素-3-糖苷单独或纯化的花青素单独。 药学上可接受的载体与多酚活性成分一起给药。
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3.发明授权Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia 失效用于治疗肥胖症，胰岛素相关疾病和高胆固醇血症的方法和组合物公开(公告)号：US08198249B2
公开(公告)日：2012-06-12
申请号：US12773277
申请日：2010-05-04
IPC分类号： A61K31/7048 , A61K31/353
CPC分类号： A61K31/353 , A61K31/57 , A61K31/7048
摘要： A process of enhancing insulin excretion in a subject includes administering to the subject a polyphenol active ingredient. The polyphenol active ingredient is a purified cyanidin-3-glycoside alone or purified cyanidin alone. The pharmaceutically acceptable carrier is administered with the polyphenol active ingredient.
摘要翻译： 增加受试者胰岛素排泄的过程包括向受试者施用多酚活性成分。 多酚活性成分是纯化的花青素-3-糖苷单独或纯化的花青素单独。 药学上可接受的载体与多酚活性成分一起给药。
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4.发明申请METHODS AND COMPOSITIONS FOR THE TREATMENT OF OBESITY, INSULIN RELATED DISEASES AND HYPERCHOLESTEROLEMIA 失效治疗肥胖，胰岛素相关疾病和高脂血症的方法和组合公开(公告)号：US20110003762A1
公开(公告)日：2011-01-06
申请号：US12773277
申请日：2010-05-04
IPC分类号： A61K31/7048 , A61K31/353 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A61K31/353 , A61K31/57 , A61K31/7048
摘要： A process of enhancing insulin excretion in a subject includes administering to the subject a polyphenol active ingredient. The polyphenol active ingredient is a purified cyanidin-3-glycoside alone or purified cyanidin alone. The pharmaceutically acceptable carrier is administered with the polyphenol active ingredient.
摘要翻译： 增加受试者胰岛素排泄的过程包括向受试者施用多酚活性成分。 多酚活性成分是纯化的花青素-3-糖苷单独或纯化的花青素单独。 药学上可接受的载体与多酚活性成分一起给药。
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公开(公告)号：US07195784B2
公开(公告)日：2007-03-27
申请号：US10294106
申请日：2002-11-14
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
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公开(公告)号：US07737121B2
公开(公告)日：2010-06-15
申请号：US11071929
申请日：2005-03-04
IPC分类号： A61K31/7048 , A61K31/70
CPC分类号： A61K31/353 , A61K31/7048
摘要： A method for stimulating insulin secretion by anthocyanidins and anthocyanins is described. The secretion can be in vivo in mammals, including humans, or in vitro.
摘要翻译： 描述了通过花青素和花青素刺激胰岛素分泌的方法。 哺乳动物，包括人体内或体外可分泌体内。
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公开(公告)号：US07282593B2
公开(公告)日：2007-10-16
申请号：US10918284
申请日：2004-08-13
IPC分类号： C07D405/00
CPC分类号： C07H17/02
摘要： Novel isolated and purified withanamides and withanolides are described. In particular, compounds from Withania somnifera fruit are the preferred source of the withanamides and withanolides, although they can be from other plant sources. In addition to their use as powerful antioxidants, the withanamides and withanolides can be useful for the treatment of depression, Alzheimer's Disease, obesity and migraine headaches.
摘要翻译： 描述了新型分离和纯化的酰胺和脱乙酰壳多糖。 特别地，来自无花果实果实的化合物是与酰胺和脱乙酰壳多糖的优选来源，尽管它们可以来自其他植物来源。 除了它们作为强力抗氧化剂的用途之外，对苯二胺和助死苷可用于治疗抑郁症，阿尔茨海默病，肥胖症和偏头痛。
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公开(公告)号：US07270836B2
公开(公告)日：2007-09-18
申请号：US11406749
申请日：2006-04-19
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
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公开(公告)号：US07264832B2
公开(公告)日：2007-09-04
申请号：US11406798
申请日：2006-04-19
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
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公开(公告)号：US07264831B2
公开(公告)日：2007-09-04
申请号：US11406751
申请日：2006-04-19
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
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