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1.发明授权Processes for the manufacture of macrocyclic depsipeptides and new intermediates 失效用于制备大环脱肽和新中间体的方法公开(公告)号：US08614289B2
公开(公告)日：2013-12-24
申请号：US13449937
申请日：2012-04-18
申请人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
发明人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
摘要： The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
摘要翻译： 本发明涉及用于化学制备式I的缩酚酸肽的方法或方法，其中符号具有在描述中定义的含义，新的中间体及其制备以及相关的发明实施方案。
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公开(公告)号：US09278997B2
公开(公告)日：2016-03-08
申请号：US14082315
申请日：2013-11-18
申请人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
发明人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
IPC分类号： A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K11/02 , C07K7/06 , C07K11/00 , A61K38/00
摘要： The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
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3.发明申请Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates 审中-公开制备大环肽和新型中间体的方法公开(公告)号：US20140080995A1
公开(公告)日：2014-03-20
申请号：US14082315
申请日：2013-11-18
申请人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
发明人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
摘要： The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
摘要翻译： 本发明涉及用于化学制备式I的缩酚酸肽的方法或方法，其中符号具有在描述中定义的含义，新的中间体及其制备以及相关的发明实施方案。
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4.发明授权公开(公告)号：US09493512B2
公开(公告)日：2016-11-15
申请号：US14686899
申请日：2015-04-15
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K11/00 , C07K11/02 , C07K7/06 , C07C235/74 , C07K5/093
CPC分类号： C07K11/00 , A61K38/00 , C07C235/74 , C07K5/0819 , C07K7/06 , C07K11/02
摘要： The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
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5.发明授权公开(公告)号：US09067978B2
公开(公告)日：2015-06-30
申请号：US14045844
申请日：2013-10-04
CPC分类号： C07K11/00 , A61K38/00 , C07C235/74 , C07K5/0819 , C07K7/06 , C07K11/02
摘要： The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
摘要翻译： 本发明涉及用于溶液相化学制备式I的缩酚酸肽的方法或方法，其中符号具有在描述中定义的含义，新的中间体及其制备以及相关的发明实施方案。
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6.发明授权Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates 有权用于制备大环脱脂肽和新中间体的基于醛缩乙醛的方法公开(公告)号：US08987413B2
公开(公告)日：2015-03-24
申请号：US14042950
申请日：2013-10-01
IPC分类号： A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K11/02 , C07D317/30 , C07C229/22 , C07K7/06
CPC分类号： C07K11/02 , C07C43/164 , C07C229/12 , C07C229/22 , C07C233/47 , C07D317/30 , C07K7/02 , C07K7/04 , C07K7/06 , C07K11/00
摘要： The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
摘要翻译： 本发明涉及使用醛缩醛中间体化学制备式I的缩肽的方法或方法，其中符号具有本说明书中定义的含义，新的中间体及其制备以及相关的发明实施方案。
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公开(公告)号：US20150218223A1
公开(公告)日：2015-08-06
申请号：US14681226
申请日：2015-04-08
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译： 本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或 其复合物，其具有有趣的药物性质。
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公开(公告)号：US20050014686A1
公开(公告)日：2005-01-20
申请号：US10343288
申请日：2001-07-30
申请人： Rainer Albert , Wlifried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meissenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wlifried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meissenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： A61K45/00 , A61K38/00 , A61K38/04 , A61K38/28 , A61K49/00 , A61K49/04 , A61K51/00 , A61P1/00 , A61P1/04 , A61P1/12 , A61P1/18 , A61P5/10 , A61P5/48 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P13/12 , A61P27/02 , A61P29/00 , A61P31/18 , A61P35/00 , C07K1/06 , C07K7/64 , C07K14/655 , A61K38/12
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译： 本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或 其复合物，其具有有趣的药物性质。
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公开(公告)号：US20110166320A1
公开(公告)日：2011-07-07
申请号：US13048935
申请日：2011-03-16
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
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公开(公告)号：US07939625B2
公开(公告)日：2011-05-10
申请号：US12265135
申请日：2008-11-05
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译： 本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或 其复合物，其具有有趣的药物性质。
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