公开(公告)号：US20180030038A1

公开(公告)日：2018-02-01

申请号：US15225015

申请日：2016-08-01

申请人： Mylan Laboratories Ltd.

发明人： Ramakoteswara Rao Jetti ,  Anjaneyaraju Indukuri ,  Satish Beeravelly ,  Asharani Gorantla ,  B.A. Ramireddy ,  Ruchira M. Sarbajna ,  Sivalakshmidevi Arikatla

IPC分类号： C07D405/12

CPC分类号： C07D405/12 ,  C07B2200/13 ,  C07C69/60

摘要： The present disclosure relates to amorphous and crystalline forms of 2-butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-,(2E)-, (2Z)-2-butenedioate (1:2) (afatinib dimaleate). The present disclosure also relates to process for the preparation of amorphous and crystalline forms of afatinib dimaleate. Further, the present disclosure relates to solid dispersion of amorphous afatinib dimaleate and the crystalline form of afatinib.

公开(公告)号：US10087193B2

公开(公告)日：2018-10-02

申请号：US15114991

申请日：2015-02-04

申请人： Mylan Laboratories Ltd.

发明人： Ramakoteswara Rao Jetti ,  Satish Beeravelly ,  Madhu Murthy Nadella ,  Haribabu Nandipati

IPC分类号： C07D498/14

摘要： The present disclosure relates to novel crystalline dolutegravir sodium Form-M2, Form-M3, Form-M4 and process for the preparation thereof.