-
公开(公告)号：US12076353B2
公开(公告)日：2024-09-03
申请号：US16763013
申请日：2018-11-23
发明人： Jean-Simon Diallo , Mohammed Selman , Rozanne Arulanandam , Nicole Elise Forbes , Ramya Krishnan
IPC分类号： C12N7/00 , A61K31/225 , A61K35/766 , A61P35/00 , C07C69/60 , A61K39/00
CPC分类号： A61K35/766 , A61K31/225 , A61P35/00 , C07C69/60 , C12N7/00 , A61K2039/585 , C12N2710/10332 , C12N2710/10351 , C12N2740/16134 , C12N2760/16134 , C12N2760/16151 , C12N2760/20232 , C12N2760/20251
摘要： Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
-
公开(公告)号：US20180261771A1
公开(公告)日：2018-09-13
申请号：US15975224
申请日：2018-05-09
申请人： LOMOX LIMITED
IPC分类号： H01L51/00 , C07C43/225 , C07C69/593 , C07C69/60 , C07C69/92 , C07D207/452 , C07D207/46 , C07D285/14 , C07D417/14 , C08G61/12 , C09K11/02 , C09K19/32 , C07C65/21 , H01L51/05 , H01L51/42 , H01L51/50
CPC分类号： H01L51/0039 , C07C43/225 , C07C65/21 , C07C69/593 , C07C69/60 , C07C69/92 , C07C2603/18 , C07D207/452 , C07D207/46 , C07D285/14 , C07D417/14 , C08G61/121 , C08G2261/146 , C08G2261/228 , C08G2261/312 , C08G2261/3142 , C08G2261/3221 , C08G2261/3223 , C08G2261/3246 , C08G2261/512 , C08G2261/53 , C08G2261/76 , C08G2261/91 , C08G2261/92 , C08G2261/95 , C09K11/025 , C09K19/32 , H01L51/0035 , H01L51/0036 , H01L51/005 , H01L51/0052 , H01L51/0068 , H01L51/0071 , H01L51/0076 , H01L51/0512 , H01L51/42 , H01L51/5012 , H01L51/5056 , Y02E10/549
摘要： Compounds of the formula D-S1-A-S2—B1 wherein A comprises a 2,7-disubstituted 9,9-fluoroalkyl fluorene diradical of the formula wherein S1, S2, D and B1 have meanings given in the description that are useful as charge transport and emissive materials for the fabrication of electronic devices such as diodes, transistors, and photovoltaic devices.
-
公开(公告)号：US10071969B2
公开(公告)日：2018-09-11
申请号：US14949489
申请日：2015-11-23
申请人： MannKind Corporation
发明人： Kelly Sullivan Kraft , John J. Freeman , Paul Serwinski , Vincent Pavia , Otto Phanstiel , Navneet Kaur
IPC分类号： C07D241/08 , C07C201/12 , C07C67/39 , C07C67/30
CPC分类号： C07D241/08 , C07C67/30 , C07C67/39 , C07C201/12 , C07C69/60 , C07C205/43
摘要： Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphophoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.
-
公开(公告)号：US20180103667A1
公开(公告)日：2018-04-19
申请号：US15539013
申请日：2015-12-21
申请人： Firmenich SA
IPC分类号： A23L27/20 , A23L2/56 , A23L27/29 , C07D307/12 , C07C69/44 , C07C69/40 , C07C69/60 , C07C69/38
CPC分类号： A23L27/2024 , A23L2/56 , A23L27/29 , A23L27/72 , C07C69/38 , C07C69/40 , C07C69/44 , C07C69/60 , C07D307/12
摘要： Provided herein are flavor particles containing encapsulated precursors of acetylaldehyde. Also provided herein are methods of making and using the particles.
-
公开(公告)号：US20180030038A1
公开(公告)日：2018-02-01
申请号：US15225015
申请日：2016-08-01
发明人： Ramakoteswara Rao Jetti , Anjaneyaraju Indukuri , Satish Beeravelly , Asharani Gorantla , B.A. Ramireddy , Ruchira M. Sarbajna , Sivalakshmidevi Arikatla
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , C07B2200/13 , C07C69/60
摘要： The present disclosure relates to amorphous and crystalline forms of 2-butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-,(2E)-, (2Z)-2-butenedioate (1:2) (afatinib dimaleate). The present disclosure also relates to process for the preparation of amorphous and crystalline forms of afatinib dimaleate. Further, the present disclosure relates to solid dispersion of amorphous afatinib dimaleate and the crystalline form of afatinib.
-
公开(公告)号：US09796659B2
公开(公告)日：2017-10-24
申请号：US15112683
申请日：2015-02-27
申请人： RATIOPHARM GMBH
发明人： Wolfgang Albrecht , Frank Lehmann , Roland Selig , Sebastian Rabe , Annemarie Maier , Richard Guserle
IPC分类号： C07C69/60 , C07C229/22 , A61K9/00 , A61K31/225 , C07C69/604
CPC分类号： C07C69/60 , A61K9/0053 , A61K31/225 , C07C69/604 , C07C229/22
摘要： The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
-
公开(公告)号：US09695268B2
公开(公告)日：2017-07-04
申请号：US14573733
申请日：2014-12-17
IPC分类号： C08G18/32 , C08G18/66 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/42 , C08G18/77 , C08G18/73
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula (I)
-
8.发明申请ANAEROBIC CURABLE COMPOSITIONS CONTAINING BLOCKED (METH)ACRYLIC ACID COMPOUNDS 有权含有嵌段（甲基）丙烯酸化合物的无水可固化组合物公开(公告)号：US20170044088A1
公开(公告)日：2017-02-16
申请号：US15340385
申请日：2016-11-01
IPC分类号： C07C69/54 , C09J133/14 , C08F220/28
CPC分类号： C07C69/60 , C07C69/54 , C08F2/44 , C08F220/28 , C08F222/02 , C08F2220/281 , C08F2220/286 , C08L33/06 , C09J4/06 , C09J133/06 , C09J133/14 , C09K3/1006 , C09K2003/1065 , C09K2200/0625 , C08F265/06 , C08F222/06
摘要： The present invention relates to anaerobic curable compositions, such as adhesives and sealants, containing blocked acrylic acid compounds. The blocked acrylic acid compounds are labile (meth)acrylic acid compounds having an acetal linkage, which cleaves to release (meth)acrylic acid during anaerobic cure. In this way, the block acrylic acid compounds acts as an adhesion promoter thereby promoting adhesion to various substrates.
摘要翻译： 本发明涉及含有封闭的丙烯酸化合物的厌氧可固化组合物，例如粘合剂和密封剂。 封闭的丙烯酸化合物是具有缩醛键的不稳定（甲基）丙烯酸化合物，其在厌氧固化期间裂解释放（甲基）丙烯酸。 以这种方式，嵌段丙烯酸化合物起粘合促进剂的作用，从而促进对各种基材的粘附。
-
公开(公告)号：US20170001945A1
公开(公告)日：2017-01-05
申请号：US15112683
申请日：2015-02-27
申请人： RATIOPHARM GMBH
发明人： Wolfgang ALBRECHT , Frank LEHMANN , Roland SELIG , Sebastian RABE , Annemarie MAIER , Richard GUSERLE
IPC分类号： C07C69/60 , A61K9/00 , A61K31/225 , C07C229/22 , C07C69/604
CPC分类号： C07C69/60 , A61K9/0053 , A61K31/225 , C07C69/604 , C07C229/22
摘要： The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
摘要翻译： 本发明涉及新化合物，例如， 用作药物。 特别地，本发明涉及适合作为药物，优选用于治疗和/或预防全身性疾病，自身免疫性疾病，炎性疾病，例如多发性硬化和牛皮癣的富马酸单甲酯（MMF）的新型前体药物。
-
公开(公告)号：US20160340291A1
公开(公告)日：2016-11-24
申请号：US15227083
申请日：2016-08-03
发明人： Benjamin Amorelli , Edward Mark Arruda , Robert P. Belko , Tingwei Cai , Adam P. Closson , Nicole L. Giffin , Gary J. Mertz , Michael G. Monteleone
IPC分类号： C07C69/75 , A61Q15/00 , A61K8/37 , C11D3/50 , A61Q19/00 , A61Q11/00 , A61Q5/00 , A61Q19/10 , C11B9/00 , A61Q13/00
CPC分类号： C07C69/75 , A61K8/33 , A61K8/36 , A61K8/37 , A61K8/498 , A61Q5/00 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C07C43/162 , C07C47/21 , C07C49/385 , C07C49/587 , C07C69/60 , C07C69/96 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07D307/83 , C07D307/87 , C11B9/0015 , C11B9/0019 , C11B9/0034 , C11B9/0038 , C11B9/0076 , C11D3/2072 , C11D3/50
摘要： The present invention relates to novel compounds and their use as fragrance materials.
-
-
-
-
-
-
-
-
-
搜索结果
301 条记录 (耗时 0.028 秒)
