公开(公告)号：US08709142B2

公开(公告)日：2014-04-29

申请号：US13356395

申请日：2012-01-23

申请人： Mytia V. Story ,  Darlene P. Story

发明人： Mytia V. Story ,  Darlene P. Story

IPC分类号： C09D11/00

CPC分类号： C09D11/20 ,  A61K8/19 ,  A61K8/345 ,  A61K8/553 ,  A61K8/8176 ,  A61Q1/025 ,  C09D11/033 ,  C09D11/037

摘要： An ink formulation for marking living tissue comprises a dispersion of carbon black pigment particles encapsulated in water soluble shells, mixed with a pharmaceutically accepted carrier, such as water, and a preservative. A dispersion formulation is preferential to a suspension formulation for marking living tissue because the carbon particles of the dispersion formulation are less likely to aggregate and sediment over time. In addition, the absence of large quantities of additives makes a dispersion formulation less reactive to living tissue, further enhancing its appeal as a biological marker.

摘要翻译： 用于标记活组织的油墨制剂包括包封在水溶性壳中的炭黑颜料颗粒的分散体，与药学上可接受的载体如水混合，并且防腐剂。 分散体制剂优选用于标记活组织的悬浮液制剂，因为分散体制剂的碳颗粒不太可能随时间聚集和沉淀。 另外，不存在大量的添加剂使得分散体制剂对活组织的反应性降低，从而进一步提高其作为生物学标记的吸引力。

公开(公告)号：US20130098265A1

公开(公告)日：2013-04-25

申请号：US13356395

申请日：2012-01-23

申请人： Mytia V. Story ,  Darlene P. Story

发明人： Mytia V. Story ,  Darlene P. Story

IPC分类号： C09D11/00

CPC分类号： C09D11/20 ,  A61K8/19 ,  A61K8/345 ,  A61K8/553 ,  A61K8/8176 ,  A61Q1/025 ,  C09D11/033 ,  C09D11/037

摘要： An ink formulation for marking living tissue comprises a dispersion of carbon black pigment particles encapsulated in water soluble shells, mixed with a pharmaceutically accepted carrier, such as water, and a preservative. A dispersion formulation is preferential to a suspension formulation for marking living tissue because the carbon particles of the dispersion formulation are less likely to aggregate and sediment over time. In addition, the absence of large quantities of additives makes a dispersion formulation less reactive to living tissue, further enhancing its appeal as a biological marker.

摘要翻译： 用于标记活组织的油墨制剂包括包封在水溶性壳中的炭黑颜料颗粒的分散体，与药学上可接受的载体如水混合，并且防腐剂。 分散体制剂优选用于标记活组织的悬浮液制剂，因为分散体制剂的碳颗粒不太可能随时间聚集和沉淀。 另外，不存在大量的添加剂使得分散体制剂对活组织的反应性降低，从而进一步提高其作为生物学标记的吸引力。