公开(公告)号：US3364117A

公开(公告)日：1968-01-16

申请号：US39531364

申请日：1964-09-09

Applicant: NAT RES DEV

Inventor： WILLIAMS SMITH HERBERT

IPC: A61K39/02 ,  A61K39/112

CPC classification number: A61K39/0275 ,  Y10S424/825

Abstract: A vaccine compn. comprising the attenuated strain of Salmonella choleraesuis ATCC 15478 or 15479 and a pharmaceutically acceptable diluent. The compn. may be stored as a freeze dried culture and is preferably used as an injectable vaccine. Vaccine for the prevention of Salmonella choleraesuis infection (paratyphoid) in pigs. The injectable vaccine should contain 108-109 viable bacteria per ml. In 8-week old pigs a single dose of 1-10 mls. can be used.

Abstract translation: 疫苗组合 包括减毒沙门氏菌ATCC 15478或15479的菌株和药学上可接受的稀释剂。 公司 可以作为冷冻干燥培养物储存，优选用作可注射疫苗。 疫苗用于预防猪中的霍乱沙门氏菌感染（副伤寒）。 注射疫苗应含有108-109个活细菌/ ml。 在8周龄的猪中，单剂量为1-10毫升。 可以使用。

公开(公告)号：US3356574A

公开(公告)日：1967-12-05

申请号：US41547264

申请日：1964-12-02

Applicant: NAT RES DEV

Inventor： WILLIAMS SMITH HERBERT

IPC: A61K39/02 ,  A61K39/112 ,  C12N1/36

CPC classification number: A61K39/0275 ,  A61K2039/522 ,  C12N1/36 ,  Y10S424/823 ,  Y10S435/879

Abstract: A vaccine for combating Salmonella dublin infection in calves comprises the strain of Salmonella dublin having the A.T.C.C. deposit number 15480 and a pharmaceutically acceptable diluent. The vaccine is preferably in the form of an injectable composition and may be formulated using freeze-dried organisms. The organisms may be harvested from an ordinary culture and re-suspended in conventional diluents or a broth culture of the organisms may be used as the vaccine. Useful degrees of immunity against Salmonella dublin infection in calves are also obtained by vaccines comprising a live attenuated strain of Salmonella gallinarum, and a mixed vaccine containing the above Salmonella dublin vaccine and Salmonella gallinarum vaccine. The Salmonella dublin vaccine may be used as a prophylactic measure against related Salmonella infections, e.g. Salmonella typhimurium infections.

Abstract translation: 用于防治小牛沙门氏菌都柏林感染的疫苗包括具有A.T.C.C.的都柏林沙门氏菌菌株。 保藏号15480和药学上可接受的稀释剂。 疫苗优选为可注射组合物的形式，并且可以使用冷冻干燥的生物进行配制。 生物可以从普通培养物中收获并重新悬浮在常规稀释剂中，或者生物体的肉汤培养物可以用作疫苗。 还可以通过包含减毒沙门氏菌沙门氏菌菌株的疫苗和含有上述沙门氏沙门氏菌疫苗和沙门氏菌沙门氏菌疫苗的混合疫苗获得对小牛中都柏林沙门氏菌感染的有用程度的免疫。 沙门氏菌都柏林疫苗可用作预防措施以抵抗相关的沙门氏菌感染，例如， 鼠伤寒沙门氏菌感染。