公开(公告)号：US20240082391A1

公开(公告)日：2024-03-14

申请号：US18260133

申请日：2022-01-05

申请人： NATIONAL RESEARCH COUNCIL OF CANADA

发明人： Yimei JIA ,  Michael MCCLUSKIE ,  Bassel AKACHE ,  Lakshmi KRISHNAN

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/215 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K39/00119 ,  A61K39/215 ,  A61P35/00 ,  A61P37/04 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/572 ,  A61K2039/575

摘要： Provided is an adjuvant composition comprising a glycoarchaeol and at least one immunostimulantselected from a Toll-like receptor (TLR) agonist and a saponin. The glycoarchaeol and/orimmunostimulant may be present as a pharmaceutically acceptable salt. The adjuvant compositionmay be comprised together with an antigen in an immunogenic composition, such as a vaccine composition, which may be for use to induce an immune response in a subject. Further provided isuse of the immunogenic composition to induce an immune response in a subject, particularly animmune response that comprises both a cell-mediated response and a humoral response.