公开(公告)号：US20240018484A1

公开(公告)日：2024-01-18

申请号：US18452952

申请日：2023-08-21

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： Pan-Chyr Yang ,  Huei-Wen Chen ,  Wan-Jiun Chen

IPC分类号： C12N5/095 ,  C12N5/09 ,  G01N33/50 ,  G01N33/574

CPC分类号： C12N5/0695 ,  C12N5/0693 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/5011 ,  G01N33/57492 ,  G01N33/57496 ,  C12N2502/30 ,  C12N2501/605 ,  G01N2800/52 ,  G01N2333/4706 ,  G01N2333/475 ,  G01N2333/4753 ,  G01N2333/52 ,  G01N2333/71 ,  G01N2333/715 ,  G01N2333/7158

摘要： An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.

公开(公告)号：US12085570B2

公开(公告)日：2024-09-10

申请号：US16475957

申请日：2018-01-03

申请人： National Taiwan University

发明人： Pan-Chyr Yang ,  Huei-Wen Chen ,  Wan-Jiun Chen

IPC分类号： C12Q1/6886 ,  G01N33/574

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57492 ,  C12Q2600/112 ,  G01N2333/70585 ,  G01N2333/70596 ,  G01N2800/56

摘要： Provided herein are methods and kits for analyzing a sample such as a biological sample obtained from a subject having, suspected of having, or being at risk for a cancer to assess presence of cancer stem cells in the sample, which is indicative of poor cancer prognosis.

公开(公告)号：US11834682B2

公开(公告)日：2023-12-05

申请号：US17121375

申请日：2020-12-14

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： Pan-Chyr Yang ,  Huei-Wen Chen ,  Wan-Jiun Chen

IPC分类号： C12N5/095 ,  C12N5/09 ,  G01N33/50 ,  G01N33/574

CPC分类号： C12N5/0695 ,  C12N5/0693 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/57492 ,  G01N33/57496 ,  C12N2501/605 ,  C12N2502/30 ,  G01N2333/475 ,  G01N2333/4706 ,  G01N2333/4753 ,  G01N2333/52 ,  G01N2333/71 ,  G01N2333/715 ,  G01N2333/7158 ,  G01N2800/52

摘要： An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.

公开(公告)号：US20210115409A1

公开(公告)日：2021-04-22

申请号：US17121375

申请日：2020-12-14

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： Pan-Chyr Yang ,  Huei-Wen Chen ,  Wan-Jiun Chen

IPC分类号： C12N5/095 ,  C12N5/09 ,  G01N33/50 ,  G01N33/574

摘要： An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.

公开(公告)号：US20180230435A1

公开(公告)日：2018-08-16

申请号：US15513804

申请日：2014-09-24

申请人： Andrew Man Chung WO ,  National Taiwan University

发明人： Pan-Chyr Yang ,  Huei-Wen Chen ,  Wan-Jiun Chen

IPC分类号： C12N5/095 ,  C12N5/09 ,  G01N33/50 ,  G01N33/574

CPC分类号： C12N5/0695 ,  C12N5/0693 ,  C12N2501/605 ,  C12N2502/30 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/57492 ,  G01N33/57496 ,  G01N2333/4706 ,  G01N2333/475 ,  G01N2333/4753 ,  G01N2333/52 ,  G01N2333/71 ,  G01N2333/715 ,  G01N2333/7158 ,  G01N2800/52

摘要： An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.