公开(公告)号：US20250012812A1

公开(公告)日：2025-01-09

申请号：US18291509

申请日：2022-07-22

Applicant: The University of Tokyo ,  Kanagawa Prefectural Hospital Organization ,  Tokyo Institute of Technology ,  National University Corporation Kanazawa University

Inventor： Motoharu Seiki ,  Taro Yamashita ,  Hikari Okada ,  Shuichi Kaneko ,  Naohiko Koshikawa ,  Nobuaki Funahashi

IPC: G01N33/68

Abstract: The present invention provides a method of detecting a biomarker for detecting hepatocytes with bile ductular proliferation, the method including: detecting laminin γ2 single chain or a nucleic acid encoding the same as the biomarker in a specimen.

公开(公告)号：US09512491B2

公开(公告)日：2016-12-06

申请号：US14551674

申请日：2014-11-24

Applicant: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY

Inventor： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

IPC: C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.

公开(公告)号：US09512490B2

公开(公告)日：2016-12-06

申请号：US14551666

申请日：2014-11-24

Applicant: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY

Inventor： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

IPC: C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.

公开(公告)号：US09441276B2

公开(公告)日：2016-09-13

申请号：US14551651

申请日：2014-11-24

Applicant: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY

Inventor： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

IPC: C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles. The method comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.

Abstract translation: 本发明提供了一种用于基于表达谱来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂。 该方法包括获得选自对应于在消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌中变化的表达水平（在外周血中）的基因的探针中的至少一种基因的表达谱。 病例与正常健康受试者相比。 用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在 消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。