公开(公告)号：US20210054061A1

公开(公告)日：2021-02-25

申请号：US17050384

申请日：2019-04-15

申请人： NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY ,  NIIGATA UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY ,  KAWASAKI GAKUENN EDUCATIONAL FOUNDATION

发明人： Masakiyo SAKAGUCHI ,  Shinichi TOYOOKA ,  Shuta TOMIDA ,  Kazuhiko SHIEN ,  Hiroki SATO ,  Rie KINOSHITA ,  Junichiro FUTAMI ,  Kota ARAKI ,  Mikio OKAZAKI ,  Eisaku KONDO ,  Yusuke INOUE ,  Akira YAMAUCHI

IPC分类号： C07K16/24 ,  A61P35/04 ,  A61P11/00

摘要： Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.