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1.发明申请PROBE, SYSTEM, AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD ANALYTES 审中-公开探针，系统和方法用于血液分析仪的非入血测量公开(公告)号：US20160235345A1
公开(公告)日：2016-08-18
申请号：US15026312
申请日：2014-10-01
发明人： Daniel Perez Calero , James Peter Robert Day , Jacobus Thomas Wilhelmus Elisabeth Vogels , Maarten J. Scholtes-Timmerman , Jacobus Johannes Frederik van Veen
IPC分类号： A61B5/1455 , A61B5/145
摘要： The present disclosure concerns a measuring probe (10) for non-invasive in vivo measurement of blood analytes (33) by Raman spectroscopy. The measuring probe (10) comprises a housing (20) having a skin engaging surface (21). The housing (20) comprises a first optical system (1, 3, 4) arranged for providing source light (11) to the skin engaging surface (21) for penetrating a subject's skin (31) by said source light (11) for interacting with the blood analytes (33). The housing (20) further comprises a second optical system (5, 6, 2) arranged for capturing scattered Raman light (12) from the blood analytes (33) for measurement of the blood analytes (33). The first optical system (1, 3, 4) is arranged for providing the source light (11) as a collimated beam (1c) onto the skin (31).
摘要翻译： 本公开涉及用于通过拉曼光谱学非血管分析物（33）的非侵入式体内测量的测量探针（10）。 测量探针（10）包括具有皮肤接合表面（21）的壳体（20）。 壳体（20）包括第一光学系统（1,3,4），其被设置用于向皮肤接合表面（21）提供源光（11），用于通过所述源光（11）穿透受试者的皮肤（31）以进行相互作用 与血液分析物（33）。 壳体（20）还包括布置成用于从血液分析物（33）捕获散射的拉曼光（12）以测量血液分析物（33）的第二光学系统（5,6）。 第一光学系统（1,3,4）布置成将源光（11）作为准直光束（1c）提供到皮肤（31）上。
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公开(公告)号：US10478106B2
公开(公告)日：2019-11-19
申请号：US15026312
申请日：2014-10-01
发明人： Daniel Perez Calero , James Peter Robert Day , Jacobus Thomas Wilhelmus Elisabeth Vogels , Maarten J. Scholtes-Timmerman , Jacobus Johannes Frederik van Veen
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/145 , G01N21/65 , A61B90/30
摘要： The present disclosure concerns a measuring probe (10) for non-invasive in vivo measurement of blood analytes (33) by Raman spectroscopy. The measuring probe (10) comprises a housing (20) having a skin engaging surface (21). The housing (20) comprises a first optical system (1, 3, 4) arranged for providing source light (11) to the skin engaging surface (21) for penetrating a subject's skin (31) by said source light (11) for interacting with the blood analytes (33). The housing (20) further comprises a second optical system (5, 6, 2) arranged for capturing scattered Raman light (12) from the blood analytes (33) for measurement of the blood analytes (33). The first optical system (1, 3, 4) is arranged for providing the source light (11) as a collimated beam (1c) onto the skin (31).
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公开(公告)号：US09778195B2
公开(公告)日：2017-10-03
申请号：US14893322
申请日：2014-05-23
CPC分类号： G01N21/65 , B01D53/1425 , B01D53/1475 , B01D53/1493 , B01D53/18 , B01D53/62 , B01D2252/204 , B01D2258/0283 , G01J3/44 , G01J2003/4424 , G01N1/44 , G01N21/49 , G01N21/658 , G01N2021/8416 , G01N2201/06113 , G01N2201/0697 , Y02C10/06
摘要： The present disclosure concerns a method and detector (10) for detecting an analyte (1) in a sample volume (2), such as nitrosamine in an amine solvent. The method comprises measuring a resonance Raman spectrum (I1) with a first light beam (PI) matching an electronic transition of the analyte (1). The detection of the analyte is enhanced by measuring an off-resonance Raman spectrum (12) using a second light beam (P2) that is shifted in wavelength at least 10 nm away from the electronic resonance. The resonance Raman signal (S1) of the analyte (1) is isolated from the background (Q1, Q2) by a difference analysis between the resonance and off-resonance Raman spectra (I1, I2). The method and detector (10) can be employed for detecting nitrosamine in a carbon capture process or plant (20) that employs an amine solvent.
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公开(公告)号：US10288481B2
公开(公告)日：2019-05-14
申请号：US15104755
申请日：2014-12-16
发明人： James Peter Robert Day , Kees Moddemeijer , Daniel Perez Calero , Tom Duivenvoorde , Marijn Sandtke
摘要： The present disclosure concerns a spectrometer (10) and method for generating a two dimensional spectrum (S). The spectrometer (10) comprises a main grating (3) and cross dispersion element (2). An imaging mirror (4) is arranged for reflecting and focussing dispersed radiation (R3) from the main grating (3) towards an image plane (IP) for imaging the two dimensional spectrum (S) onto an image plane (IP) of the spectrometer (10). A correction lens (6) is arranged for correcting optical aberrations in the imaging of the two dimensional spectrum (S) in the image plane (IP). The imaging mirror (4) and correction lens (6) have a coinciding axis of cylindrical symmetry (AS).
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公开(公告)号：US10234331B2
公开(公告)日：2019-03-19
申请号：US15026283
申请日：2014-10-01
摘要： The present disclosure concerns a monolithic spectrometer for spectrally resolving light. The spectrometer comprises a body of solid material having optical surfaces arranged to guide the light along an optical path inside the body. A collimating surface and focusing surface are part of a single surface having a continuous optically functional shape. The surfaces of the body are arranged to have a third or fourth part of the optical path between a grating surface and an exit surface cross with a first part of the optical path between an entry surface and a collimating surface.
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公开(公告)号：US20160245693A1
公开(公告)日：2016-08-25
申请号：US15026283
申请日：2014-10-01
CPC分类号： G01J3/0259 , G01J3/0208 , G01J3/0291 , G01J3/18 , G01J3/2823
摘要： The present disclosure concerns a monolithic spectrometer (1) for spectrally resolving light (R). The spectrometer (1) comprises a body (2) of solid material having optical surfaces (3, 4, 5, 6, 8) arranged to guide the light (R) along an optical path (E1, E2, E3, E4) inside the body (2). A collimating surface (4) and focusing surface (6) are part of a single surface having a continuous optically functional shape. The surfaces (3,4,5,6,8) of the body (2) are arranged to have a third or fourth part (E3, E4) of the optical path between a grating surface (5) and an exit surface (8) cross (C) with a first part (E1) of the optical path between an entry surface (3) and a collimating surface (4).
摘要翻译： 本公开涉及用于光谱分辨光（R）的单片光谱仪（1）。 光谱仪（1）包括具有光学表面（3,4,5,6,8）的固体材料体（2），其被布置成沿着光线（E1，E2，E3，E4）内的光路 身体（2）。 准直表面（4）和聚焦表面（6）是具有连续光学功能形状的单个表面的一部分。 主体（2）的表面（3,4,5,6,8）布置成具有在光栅表面（5）和出射表面（8）之间的光路的第三或第四部分（E3，E4） ）与进入表面（3）和准直表面（4）之间的光路的第一部分（E1）交叉（C）。
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