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公开(公告)号：US20230043970A1
公开(公告)日：2023-02-09
申请号：US17506367
申请日：2021-10-20
Applicant: NEUPHARMA, INC
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: C07D239/74 , C07D403/12 , A61K45/06 , C07D403/04 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D471/04 , C07D473/32 , C07D487/04
Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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公开(公告)号：US20210163423A1
公开(公告)日：2021-06-03
申请号：US17172435
申请日：2021-02-10
Applicant: NeuPharma, Inc.
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: C07D239/84 , C07D473/32 , A61P35/00 , A61K31/495 , C07D401/04 , C07D401/12 , C07D403/12 , C07D473/30
Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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公开(公告)号：US20200172495A1
公开(公告)日：2020-06-04
申请号：US16702936
申请日：2019-12-04
Applicant: NeuPharma, Inc.
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: C07D239/74 , C07D403/12 , A61K45/06 , C07D403/04 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D471/04 , C07D473/32 , C07D487/04
Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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公开(公告)号：US20200306259A1
公开(公告)日：2020-10-01
申请号：US16843610
申请日：2020-04-08
Applicant: NeuPharma, Inc.
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: A61K31/553 , A61K31/5377 , A61K45/06 , A61K31/517 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07C57/145 , C12Q1/6886 , G01N33/574
Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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公开(公告)号：US20170050936A1
公开(公告)日：2017-02-23
申请号：US14913336
申请日：2014-08-22
Applicant: NEUPHARMA, INC.
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: C07D239/84 , A61K31/5377 , A61K31/517 , C07D401/04 , C07C57/145 , C07D401/14 , C07D401/12 , C07D413/12 , C07D403/12 , C07D405/12 , A61K45/06 , C07D471/04
Abstract: Chemical entities that are effective as kinase inhibitors, pharmaceutical compositions and methods of treatment are disclosed. The chemical entities disclosed specifically inhibit signal transduction and cellular proliferation by modulating the activity of protein kinases to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism. The compounds include a pyrido[3,2-d]pyrimidine scaffold substituted with aromatic and heteroaromatic moieties.
Abstract translation: 公开了作为激酶抑制剂有效的化学实体，药物组合物和治疗方法。 所公开的化学实体通过调节蛋白激酶的活性调节和调节异常或不适当的细胞增殖，分化或代谢来特异性地抑制信号转导和细胞增殖。 化合物包括被芳族和杂芳族部分取代的吡啶并[3,2-d]嘧啶支架。
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Patent Agency Ranking
公开(公告)号：US20220354864A1
公开(公告)日：2022-11-10
申请号：US17681387
申请日：2022-02-25
Applicant: NeuPharma, Inc
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: A61K31/553 , A61K31/5377 , A61K45/06 , A61K31/517 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07C57/145 , C12Q1/6886 , G01N33/574
Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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公开(公告)号：US20210040048A1
公开(公告)日：2021-02-11
申请号：US16934907
申请日：2020-07-21
Applicant: NeuPharma, Inc.
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: C07D241/42 , C07D241/44 , A61K31/5377 , A61K31/498 , C07D403/04 , A61K45/06 , A61P35/00 , C07D401/12 , C07D401/04
Abstract: Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically, quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.
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公开(公告)号：US20200055828A1
公开(公告)日：2020-02-20
申请号：US16359654
申请日：2019-03-20
Applicant: NeuPharma, Inc.
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: C07D241/42 , C07D241/44 , A61K31/5377 , A61K31/498 , C07D403/04 , C07D401/12 , C07D401/04 , A61K45/06 , A61P35/00
Abstract: Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically, quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.
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公开(公告)号：US20150175601A1
公开(公告)日：2015-06-25
申请号：US14466896
申请日：2014-08-22
Applicant: NeuPharma, Inc.
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: C07D471/04 , A61K31/5377 , A61K31/517 , C07D401/12 , A61K45/06 , C07D403/12 , C07D401/14 , C07D413/12 , C07D405/12 , C07D403/04 , C07D239/84 , C07D401/04
CPC classification number: A61K31/553 , A61K31/517 , A61K31/5377 , A61K45/06 , C07C57/145 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57484 , A61K2300/00
Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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公开(公告)号：US20240197752A1
公开(公告)日：2024-06-20
申请号：US18519150
申请日：2023-11-27
Applicant: NeuPharma, Inc
Inventor： Xiangping QIAN , Yong-Liang ZHU
IPC: A61K31/553 , A61K31/517 , A61K31/5377 , A61K45/06 , C07C57/145 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C12Q1/6886 , G01N33/574
CPC classification number: A61K31/553 , A61K31/517 , A61K31/5377 , A61K45/06 , C07C57/145 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C12Q1/6886 , G01N33/57484 , C12Q2600/156 , C12Q2600/158
Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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