公开(公告)号：US20210330597A1

公开(公告)日：2021-10-28

申请号：US17240405

申请日：2021-04-26

申请人： NEW JERSEY INSTITUTE OF TECHNOLOGY

发明人： Xiaoyang Xu ,  Zhongyu Li ,  William Ho

IPC分类号： A61K9/51 ,  A61K9/16

摘要： One aspect of the disclosure describes a lipid conjugated cationic molecule. Other aspects of the disclosure describes nanoparticle delivery systems and methods of making the systems are disclosed. An embodiment of the nanoparticle delivery system has sustained gene delivery properties, the nanoparticle delivery system can be synthesized using biodegradable and biocompatible polymers via self-assembly. The nanoparticle delivery system comprises a plurality of nanoparticle depots, each of which has a particle-in-particle structure, and is composed of a polymeric nanoparticle, which encapsulates cationic molecule/nucleic acid complexes, facilitating enhanced retention and prolonged release of the gene payload. The polymeric nanoparticle comprises a shell, and a nanocomplex of the cationic molecule and a polynucleotide, the nanocomplexes are distributed within the shell and/or embedded in the shell. Another embodiment of the nanoparticle delivery system has one or more nanocomplexes. The one or more nanocomplexes includes a lipid conjugated cationic molecule and a polynucleotide.

公开(公告)号：US20240173435A1

公开(公告)日：2024-05-30

申请号：US18524574

申请日：2023-11-30

申请人： NEW JERSEY INSTITUTE OF TECHNOLOGY

发明人： Xiaoyang Xu ,  Zhongyu Li ,  William Ho

IPC分类号： A61K48/00 ,  A61P17/14 ,  C12N9/22 ,  C12N15/63

CPC分类号： A61K48/0058 ,  A61P17/14 ,  C12N9/22 ,  C12N15/63

摘要： Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid.