公开(公告)号：US20220062320A1

公开(公告)日：2022-03-03

申请号：US17184758

申请日：2021-02-25

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Daryl SPINNER ,  Henrieta SCHOLTZOVA ,  Richard KASCSAK

IPC: A61K31/7088 ,  A61K48/00 ,  A61P25/28 ,  C12N15/85 ,  A61K39/00 ,  C12N15/117

Abstract: The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed.

公开(公告)号：US20190328764A1

公开(公告)日：2019-10-31

申请号：US16458966

申请日：2019-07-01

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Daryl SPINNER ,  Henrieta SCHOLTZOVA ,  Richard KASCSAK

IPC: A61K31/7088

Abstract: The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed.