公开(公告)号：US20160303208A1

公开(公告)日：2016-10-20

申请号：US15076122

申请日：2016-03-21

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Fernando GONI

IPC: A61K39/00 ,  A61K39/39

CPC classification number: A61K39/0007 ,  A61K38/18 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/555 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  A61K2039/58 ,  C07K14/4711

Abstract: The invention relates to methods for treating human amyloid disease by administration of modified Aβ peptide immunogens.

Abstract translation: 本发明涉及通过施用经修饰的Aβ肽免疫原来治疗人淀粉样蛋白病的方法。

公开(公告)号：US20230087558A1

公开(公告)日：2023-03-23

申请号：US17819059

申请日：2022-08-11

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI

IPC: C07K16/28 ,  A61P25/28

Abstract: The present application discloses a method of inhibiting the onset of cerebral amyloid angiopathy (CAA) and associated conditions in a subject including administering, to a subject at risk of developing CAA, an antibody-based molecule that binds to GPIIIa49-66 on activated platelets, under conditions effective to inhibit formation of platelet micro-clots, thereby inhibiting the onset of CAA and associated conditions. Also described is a method of reducing cerebral vascular platelet micro-clots in a subject in need thereof and a combination therapeutic that includes an antibody-based molecule that binds to GPIIIa49-66 on activated platelets, and an Alzheimer's disease therapeutic.

公开(公告)号：US20220313802A1

公开(公告)日：2022-10-06

申请号：US17610388

申请日：2020-05-11

Applicant: NEW YORK UNIVERSITY ,  INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (INTA) ,  UNIVERSIDAD DE LA REPUBLICA

Inventor： Fernando GONI ,  Thomas WISNIEWSKI ,  Lucia YIM ,  Jose Alejandro CHABALGOITY ,  Analia ELISEI

IPC: A61K39/00 ,  A61P25/28 ,  C07K14/47 ,  C07K16/28

Abstract: The present disclosure is directed to a multi-species prion protein or peptide thereof, and vaccine compositions comprising the same that are useful for the vaccination and treatment of mammalian subjects at risk of having or having prion disease. Also disclosed herein are isolated proteins and peptides, polymers, vaccines, animal bait or feed, antibodies, and methods of inhibiting the onset of or treating a prion disease.

公开(公告)号：US20190010238A1

公开(公告)日：2019-01-10

申请号：US16031418

申请日：2018-07-10

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Allal BOUTAJANGOUT

IPC: C07K16/28 ,  C07K16/10 ,  A61P25/28 ,  A61P25/18

CPC classification number: C07K16/2872 ,  A61K2039/505 ,  A61P25/18 ,  A61P25/28 ,  C07K16/1036 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34

Abstract: The present invention is directed to an anti-prion monoclonal antibody and its use for the treatment of conditions associated with or mediated by proteins or peptides having a toxic oligomeric form. These conditions include, but are not limited to, Alzheimer's disease, frontotemporal dementias, traumatic brain injury, and chronic traumatic encephalopathy.

公开(公告)号：US20220062320A1

公开(公告)日：2022-03-03

申请号：US17184758

申请日：2021-02-25

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Daryl SPINNER ,  Henrieta SCHOLTZOVA ,  Richard KASCSAK

IPC: A61K31/7088 ,  A61K48/00 ,  A61P25/28 ,  C12N15/85 ,  A61K39/00 ,  C12N15/117

Abstract: The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed.

公开(公告)号：US20190328764A1

公开(公告)日：2019-10-31

申请号：US16458966

申请日：2019-07-01

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Daryl SPINNER ,  Henrieta SCHOLTZOVA ,  Richard KASCSAK

IPC: A61K31/7088

Abstract: The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed.

公开(公告)号：US20150165005A1

公开(公告)日：2015-06-18

申请号：US14559301

申请日：2014-12-03

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Fernando GONI

IPC: A61K39/00 ,  A61K39/39 ,  A61K38/18 ,  C07K14/47

CPC classification number: A61K39/0007 ,  A61K38/18 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/555 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  A61K2039/58 ,  C07K14/4711

Abstract: The invention relates to methods for treating human amyloid disease by administration of modified Aβ peptide immunogens.

Abstract translation: 本发明涉及通过施用改良的A＆Bgr来治疗人淀粉样蛋白病的方法。 肽免疫原。