公开(公告)号：US20210171473A1

公开(公告)日：2021-06-10

申请号：US16984041

申请日：2020-08-03

申请人： NEW YORK UNIVERSITY

发明人： Paramjit S. ARORA ,  Brooke Bullock LAO ,  Richard BONNEAU ,  Kevin DREW

IPC分类号： C07D241/08 ,  C07C29/80 ,  C07C29/88

摘要： The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).