公开(公告)号：US20130252880A1

公开(公告)日：2013-09-26

申请号：US13770657

申请日：2013-02-19

申请人： NEW YORK UNIVERSITY SCHOOL OF MEDICINE

发明人： Neville Robert KALLENBACH ,  Anne W. YOUNG ,  Zhigang LIU ,  Chunhui ZHOU

IPC分类号： C07K7/02

CPC分类号： C07K7/02 ,  A61K38/10 ,  Y02A50/473

摘要： Novel dendrimeric peptide compounds are disclosed that have a formula represented by the following formula I: The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.

摘要翻译： 公开了具有由下式I表示的分子式的新颖的树状聚合肽化合物：该化合物表现出抗微生物活性并且可以制备成药物组合物并用于预防和治疗包括涉及微生物入侵的人的哺乳动物中的多种病症 。 本发明的肽特别有价值，因为它们的作用是快速的，光谱广泛的，并且对标准抗生素引发的抗性几乎无关。