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公开(公告)号：US11857604B2
公开(公告)日：2024-01-02
申请号：US16755866
申请日：2018-10-12
申请人： NH THERAGUIX , Universite Claude Bernard Lyon 1 , Centre National de La Recherche Scientifique—CNRS—
发明人： Olivier Tillement , François Lux , Fabien Rossetti , Vu-Long Tran , Clélia Mathieu , Myleva Dahan
IPC分类号： A61K38/31 , A61K47/69 , A61P35/00 , A61K33/243 , A61K9/14 , A61K31/704 , A61K49/00 , A61K49/12 , A61K49/18 , B82Y5/00 , A61K33/244 , A61K9/00
CPC分类号： A61K38/31 , A61K9/146 , A61K31/704 , A61K33/243 , A61K33/244 , A61K47/6929 , A61K49/0002 , A61K49/128 , A61K49/1881 , A61P35/00 , B82Y5/00 , A61K9/0019
摘要： The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.
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公开(公告)号：US11512003B2
公开(公告)日：2022-11-29
申请号：US16620413
申请日：2018-06-08
申请人： NH THERAGUIX , Universite Claude Bernard Lyon 1 , Centre National de La Recherche Scientifique—CNRS
摘要： The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0≤A≤6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0≤B≤5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0
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