公开(公告)号：US20210078867A1

公开(公告)日：2021-03-18

申请号：US16620413

申请日：2018-06-08

申请人： NH THERAGUIX ,  Universite Claude Bernard Lyon 1 ,  Centre National de La Recherche Scientifique - CNRS -

发明人： François LUX ,  Olivier TILLEMENT ,  Fabien ROSSETI ,  Vivek THAKARE ,  Vu Long TRAN

IPC分类号： C01B33/18 ,  A61N5/10 ,  A61K49/08

摘要： The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0≤A≤6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0≤B≤5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0