公开(公告)号：US20230405154A1

公开(公告)日：2023-12-21

申请号：US18253586

申请日：2021-11-19

申请人： NH THERAGUIX ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -

发明人： Olivier TILLEMENT ,  François LUX ,  Fabien ROSSETTI ,  Paul ROCCHI ,  Tristan DOUSSINEAU

IPC分类号： A61K49/18 ,  A61K51/12

CPC分类号： A61K49/1881 ,  A61K51/1244 ,  B82Y5/00

摘要： The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.

公开(公告)号：US20210128730A1

公开(公告)日：2021-05-06

申请号：US16628611

申请日：2018-07-04

申请人： NH THERAGUIX ,  Universite Claude Bernard Lyon 1 ,  Centre National de La Recherche Scientifique - CNRS - ,  INSERM (Institut National de la Sante et de la Recherche Médicale) ,  Institut Gustave Roussy

发明人： François LUX ,  Olivier TILLEMENT ,  Jean-Luc PERFETTINI ,  Eric DEUTSCH ,  Frédéric LAW ,  Awatef ALLOUCH

IPC分类号： A61K41/00 ,  A61P35/00 ,  A61K9/51 ,  A61N5/10 ,  A61K33/24

摘要： The invention relates to methods for treating tumors. In particular, the invention provides novel use of nanoparticles in combination with ionizing radiations for treating tumors, wherein the combined effect of nanoparticles induces senescence and/or cannibalism of the tumor cells.

公开(公告)号：US20200289623A1

公开(公告)日：2020-09-17

申请号：US16755866

申请日：2018-10-12

申请人： NH THERAGUIX ,  Universite Claude Bernard Lyon 1 ,  Centre National de La Recherche Scientifique - CNRS -

发明人： Olivier TILLEMENT ,  François LUX ,  Fabien ROSSETTI ,  Vu-Long TRAN ,  Clélia MATHIEU ,  Myleva DAHAN

IPC分类号： A61K38/31 ,  A61K31/704 ,  A61K47/69 ,  A61K49/00 ,  A61P35/00 ,  A61K49/12 ,  A61K49/18 ,  A61K9/14 ,  A61K33/243 ,  B82Y5/00

摘要： The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.

公开(公告)号：US20230346971A1

公开(公告)日：2023-11-02

申请号：US18253694

申请日：2021-11-19

申请人： NH THERAGUIX ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  MEXBRAIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  HOSPICES CIVILS DE LYON ,  INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

发明人： Olivier TILLEMENT ,  François LUX ,  Delphine VERNOS ,  Claire RODRIGUEZ-LAFRASSE ,  Thomas BRICHART ,  Marco NATUZZI ,  Alain GELOEN ,  Simon CHAMPAGNE ,  Matteo MARTINI ,  Paul ROCCHI

IPC分类号： A61K47/69 ,  A61K9/08 ,  A61P35/00 ,  A61N5/10

CPC分类号： A61K47/6935 ,  A61K9/08 ,  A61P35/00 ,  A61N5/10 ,  A61N2005/1098

摘要： The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.

公开(公告)号：US20210078867A1

公开(公告)日：2021-03-18

申请号：US16620413

申请日：2018-06-08

申请人： NH THERAGUIX ,  Universite Claude Bernard Lyon 1 ,  Centre National de La Recherche Scientifique - CNRS -

发明人： François LUX ,  Olivier TILLEMENT ,  Fabien ROSSETI ,  Vivek THAKARE ,  Vu Long TRAN

IPC分类号： C01B33/18 ,  A61N5/10 ,  A61K49/08

摘要： The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0≤A≤6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0≤B≤5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0

公开(公告)号：US20230173155A1

公开(公告)日：2023-06-08

申请号：US17997763

申请日：2021-04-30

申请人： MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  INSTITUT GUSTAVE ROUSSY ,  VETAGRO-SUP INSTITUT D'ENSEIGNEMENT SUPÉRIEUR ET DE RECHERCHE

发明人： Marco NATUZZI ,  Thomas BRICHART ,  Fabien ROSSETTI ,  Matteo MARTINI ,  François LUX ,  Olivier TILLEMENT ,  Jean-Luc PERFETTINI ,  Vanessa LOUZIER ,  Jeanne-Marie BONNET-GARIN ,  Jean-Yves AYOUB

IPC分类号： A61M1/16

CPC分类号： A61M1/1621 ,  A61M1/1654

摘要： The present invention relates to the field of medical devices, more particularly the field of devices for extracting circulating molecules from the blood of a mammal, and their therapeutic uses, in particular in treating sepsis, cytokine release syndrome and/or any other form of systemic inflammatory response or cytokine shock, caused by bacterial, parasitic, fungal or viral infections, in particular caused by a viral infection, for example coronaviruses with human respiratory tract tropism.

公开(公告)号：US20190010413A1

公开(公告)日：2019-01-10

申请号：US16068258

申请日：2017-01-12

申请人： INOVENTEAM ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Arthur MARAIS ,  Mahmoud OULD-METIDJI ,  Florian LEPOIVRE ,  Anatole COLLET ,  Matteo MARTINI ,  Fabien ROSSETTI ,  Olivier TILLEMENT ,  Antoine VANLAER ,  François GHILLEBAERT

IPC分类号： C10L1/00 ,  C10L1/30 ,  C10M171/00 ,  G01N21/64

摘要： The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.

公开(公告)号：US20230263912A1

公开(公告)日：2023-08-24

申请号：US18007254

申请日：2021-07-29

申请人： MEXBRAIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  UNIVERSITE CLAUDE BERNARD LYON 1

发明人： Olivier TILLEMENT ,  François LUX ,  Fabien ROSSETTI ,  Marco NATUZZI ,  Thomas BRICHART ,  Laurent DAVID ,  Paula NUNES DE OLIVEIRA ,  Alexandra MONTEBAULT

IPC分类号： A61K49/12 ,  C08B37/08

CPC分类号： A61K49/128 ,  C08B37/003

摘要： The invention relates to a statistical polysaccharide with a weight-average molecular weight of between 100 kDa and 1000 kDa of the following formula (I): in which: each Rc independently represents a group containing a chelating agent, each Z independently represents a binder which may be a single bond or a hydrocarbon chain containing between 1 and 12 carbon atoms, said chain able to be either linear or branched and being able to contain one or more unsaturations and being able to contain one or more heteroatoms, preferably chosen from nitrogen, oxygen, sulfur and atoms of the halogen family, x is between 0.005 and 0.7, preferably between 0.05 and 0.7, and preferentially between 0.2 and 0.6, y is between 0.01 and 0.7, preferably between 0.05 and 0.2, the ratio of y/x being greater than or equal to 0.05, preferably greater than or equal to 0.15, and the sum of x+y being greater than or equal to 0.30, preferably greater than or equal to 0.35. The invention also relates to the use of said polysaccharide in a dialysis process in order to capture at least one metal, in an MRI imaging process, in a brachytherapy process or in a process for marking foodstuffs to prevent forgeries.

公开(公告)号：US20220118164A1

公开(公告)日：2022-04-21

申请号：US17425147

申请日：2020-01-24

申请人： MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

发明人： Olivier TILLEMENT ,  François LUX ,  Marie VICTOR ,  Denise BECHET ,  Marco NATUZZI ,  Jules Tillement ,  Thomas BRICHART

IPC分类号： A61M1/36 ,  A61K47/69

摘要： The invention concerns the field of medical devices, more particularly devices for joint extraction, within an organism, of at least one metal cation and at least one target molecule. In order to do this, the device comprises: a) at least one ligand exhibiting specific affinity for the target molecule; b) at least one means for extraction of the metal cation, said means being a perfusion fluid comprising at least one chelating agent, the perfusion fluid being contained in a dialysis or microdialysis system. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of the homeostasis of metals and/or target molecules in the organism, for example neurological diseases and/or proteinopathies.

公开(公告)号：US20210205213A1

公开(公告)日：2021-07-08

申请号：US16955923

申请日：2018-12-21

申请人： MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -

发明人： François LUX ,  Olivier TILLEMENT ,  Yannick CREMILLEUX ,  Thomas BRICHART ,  Sébastien GROYER

IPC分类号： A61K9/00 ,  A61M1/16 ,  A61K9/51 ,  A61K31/395

摘要： The present invention relates to the field of medical devices, more particularly to devices for extracting metals from an organism. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of metal homeostasis in the organism, for example neurological diseases.