公开(公告)号：US20240207464A1

公开(公告)日：2024-06-27

申请号：US18556527

申请日：2022-04-20

申请人： NIHON MEDI-PHYSICS CO., LTD.

发明人： Minoru KAWATANI ,  Fumiaki TAKENAKA ,  Takahisa HANADA ,  Gota TONOYA ,  Takuya TAKEDA

IPC分类号： A61K51/10 ,  A61P35/00

CPC分类号： A61K51/1096 ,  A61K51/1027 ,  A61P35/00

摘要： A conjugate of an anti-CD20 antibody and a chelating agent. The chelating agent is chelated with a metal radionuclide, the anti-CD20 antibody and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond. A radiopharmaceutical containing the conjugate as an active ingredient.

公开(公告)号：US20240189461A1

公开(公告)日：2024-06-13

申请号：US18556582

申请日：2022-04-21

申请人： NIHON MEDI-PHYSICS CO., LTD. ,  Sumitomo Pharma Co., Ltd.

发明人： Masato YAMADA ,  Fumiaki TAKENAKA ,  Kotaro HARADA ,  Momoko OMURA ,  Mitsuhiro MATONO ,  Kumiko OTSUKI ,  Yasushi OCHIAI ,  Takayuki MURAKAMI

IPC分类号： A61K51/10 ,  A61P35/00

CPC分类号： A61K51/1045 ,  A61K51/1096 ,  A61P35/00

摘要： The present invention aims to provide a radionuclide-labeled anti-MUC5AC humanized antibody that is superior in the specificity for mucin subtype 5AC (MUC5AC) and accumulation in tumor. The present invention provides a conjugate of a radionuclide and an antibody, wherein the radionuclide is a nuclide that emits β-rays, and the antibody is a humanized antibody that specifically binds to mucin subtype 5AC and has a heavy chain variable region consisting of the amino acid sequence shown in any of SEQ ID NOs: 1 to 4, and a light chain variable region consisting of the amino acid sequence shown in any of SEQ ID NOs: 5 to 8.