公开(公告)号：US20230248854A1

公开(公告)日：2023-08-10

申请号：US17769657

申请日：2020-10-16

Applicant: NIHON MEDI-PHYSICS CO., LTD.

Inventor： Akihiro IZAWA ,  Yu OGAWA ,  Hiroaki ICHIKAWA ,  Minoru KAWATANI ,  Hideaki TAKEMORI ,  Yuki OKUMURA

IPC: A61K51/10

CPC classification number: A61K51/10

Abstract: The production method of a radioactive metal-labeled antibody of the present invention includes a step of conducting a click reaction of a radioactive metal complex and an antibody site-specifically modified with a peptide to produce a radioactive metal-labeled antibody. The click reaction is performed between a first atomic group of the radioactive metal complex and a second atomic group directly or indirectly linked to the peptide. The second atomic group is an atomic group containing an azide group, or an atomic group containing trans-cyclooctene.

公开(公告)号：US20210170058A1

公开(公告)日：2021-06-10

申请号：US17047859

申请日：2019-04-15

Applicant: NIHON MEDI-PHYSICS CO., LTD. ,  National University Corporation Kagoshima University ,  National University Corporation Chiba University

Inventor： Shota KOMOTO ,  Yu OGAWA ,  Yoshinari SHOYAMA ,  Tadashi HATANO ,  Yuji ITO ,  Yasushi ARANO ,  Hiroyuki SUZUKI ,  Tomoya UEHARA

IPC: A61K51/10 ,  A61K51/08 ,  A61K51/04 ,  C07K7/08 ,  C07D257/02 ,  C07K16/32

Abstract: The present invention relates to a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and provides a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.