公开(公告)号：US20190169169A1

公开(公告)日：2019-06-06

申请号：US16211434

申请日：2018-12-06

申请人： NIHON MEDI-PHYSICS CO., LTD. ,  Kyoto University ,  National Hospital Organization

发明人： Akihiro IZAWA ,  Kei AKAMA ,  Yuki OKUMURA ,  Yurie FUKUI ,  Nobuya KOBASHI ,  Tsutomu ABE ,  Yoshihiro DOI ,  Miho IKENAGA ,  Hideo SAJI ,  Hiroyuki KIMURA ,  Mitsuhide NARUSE

IPC分类号： C07D401/14 ,  A61K51/04 ,  A61K51/00 ,  A61K31/4439

CPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K51/00 ,  A61K51/0455 ,  C07B2200/05

摘要： Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.

公开(公告)号：US20170158668A1

公开(公告)日：2017-06-08

申请号：US15321972

申请日：2015-06-25

申请人： NIHON MEDI-PHYSICS CO., LTD. ,  KYOTO UNIVERSITY ,  NATIONAL HOSPITAL ORGANIZATION

发明人： Akihiro IZAWA ,  Kei AKAMA ,  Yuki OKUMURA ,  Yurie FUKUI ,  Nobuya KOBASHI ,  Tsutomu ABE ,  Yoshihiro DOI ,  Miho IKENAGA ,  Hideo SAJI ,  Hiroyuki KIMURA ,  Mitsuhide NARUSE

IPC分类号： C07D401/14 ,  A61K51/04

CPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K51/00 ,  A61K51/0455 ,  C07B2200/05

摘要： Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.

公开(公告)号：US20210322582A1

公开(公告)日：2021-10-21

申请号：US17270946

申请日：2019-08-30

申请人： Nihon Medi-Physics Co., Ltd. ,  Kyoto University

发明人： Masato KIRIU ,  Norihito NAKATA ,  Tsutomu ABE ,  Masahiro ONO

IPC分类号： A61K51/04

摘要： The present invention provides a radiolabeled compound represented by the following formula (1), which is a radioactive imidazothiadiazole derivative compound having an affinity for CA-IX, or a salt thereof. wherein n is an integer of 1 to 4, and L represents a radionuclide or a mono- to tetravalent group containing a radionuclide.