公开(公告)号：US11116781B2

公开(公告)日：2021-09-14

申请号：US16069522

申请日：2017-01-13

Applicant: NINE B CO., LTD.

Inventor： Seon-Yong Jeong ,  Eun Kuk Park ,  Mun-Chang Kim ,  Jeong Hyun Kim

IPC: A61K31/7048 ,  A61P5/30 ,  A23L33/10 ,  A61K36/56

Abstract: A pharmaceutical composition for preventing or treating female climacteric syndromes comprising Loganin which increases the concentration of estradiol (17β-estradiol, E2) in the blood of a menopausal mouse model and has shown efficacies such as an increase in the estrogen receptor alpha expression in the uterus, which remedies uterine contraction and degeneration, and decreases in the accumulation and the size of adipocytes in liver and the abdominal adipose tissues and the liver and weight loss, a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient.