公开(公告)号：US10093923B2

公开(公告)日：2018-10-09

申请号：US14924284

申请日：2015-10-27

申请人： NITTO DENKO CORPORATION

发明人： Xiaomei Jin ,  Lei Yu ,  Hirokazu Takahashi ,  Yasunobu Tanaka ,  Yoshiro Niitsu ,  Elena Feinstein ,  Sharon Avkin-Nachum ,  Hagar Kalinski ,  Igor Mett ,  Shai Erlich ,  Elizabeth C Squiers ,  Ning Chen

IPC分类号： C07H21/04 ,  C12N15/113 ,  A61K31/713

摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.

公开(公告)号：US09206424B2

公开(公告)日：2015-12-08

申请号：US14218422

申请日：2014-03-18

申请人： NITTO DENKO CORPORATION

发明人： Xiaomei Jin ,  Lei Yu ,  Hirokazu Takahashi ,  Yasunobu Tanaka ,  Yoshiro Niitsu ,  Elena Feinstein ,  Sharon Avkin-Nachum ,  Hagar Kalinski ,  Igor Mett ,  Shai Erlich ,  Elizabeth C Squiers ,  Ning Chen

IPC分类号： C07H21/04 ,  C12N15/113 ,  A61K31/713

CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2310/3521

摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.

摘要翻译： 本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。 组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA） ）），其调节编码hsp47的基因，例如编码人hsp47的基因。 本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。