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公开(公告)号：US11103583B2
公开(公告)日：2021-08-31
申请号：US16460812
申请日：2019-07-02
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/20 , C07C323/60 , C07D333/38 , C07C271/16 , C07D333/40 , C07C317/44 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/14 , A61K9/127 , A61K47/18 , A61K47/22 , C07C237/16
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号：US10441659B2
公开(公告)日：2019-10-15
申请号：US14872951
申请日：2015-10-01
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/14 , A61K47/20 , A61K47/18 , A61K47/22 , C07C271/16 , C07D333/40 , C07C317/44 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K9/127 , C07D333/38 , C07C323/60 , C07C237/16
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号：US10093923B2
公开(公告)日：2018-10-09
申请号：US14924284
申请日：2015-10-27
发明人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C Squiers , Ning Chen
IPC分类号： C07H21/04 , C12N15/113 , A61K31/713
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
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公开(公告)号：US09636411B2
公开(公告)日：2017-05-02
申请号：US14786841
申请日：2013-04-26
发明人： Hao Bai , Kwok Yin Tsang , Yi Jin , Lei Yu
CPC分类号： A61K47/48207 , A61K47/645 , C08G69/10 , C08G73/028
摘要： Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.
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公开(公告)号：US20200085957A1
公开(公告)日：2020-03-19
申请号：US16460812
申请日：2019-07-02
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/20 , C07C323/60 , C07D333/38 , C07C271/16 , C07D333/40 , C07C317/44 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/14 , A61K9/127 , A61K47/18 , A61K47/22 , C07C237/16
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号：US09295728B2
公开(公告)日：2016-03-29
申请号：US13790995
申请日：2013-03-08
发明人： Kwok Yin Tsang , Hai Wang , Hao Bai , Yi Jin , Lei Yu
CPC分类号： A61K47/48207 , A61K47/645 , A61K49/146 , C08G69/10
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可用于各种抗癌药物递送应用的聚谷氨酸氨基酸缀合物共聚物。
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公开(公告)号：US20160074514A1
公开(公告)日：2016-03-17
申请号：US14872951
申请日：2015-10-01
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/18 , C07C237/16 , C07C323/60 , C07C317/44 , A61K9/127 , C07D333/38 , A61K47/20 , A61K47/22 , C07D207/16 , C07C237/08 , C07C333/04
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
摘要翻译： 该描述针对可用于增强脂质体中治疗剂递送的可离子化脂质。
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公开(公告)号：US20160058877A1
公开(公告)日：2016-03-03
申请号：US14786729
申请日：2013-04-26
申请人： Kwok Yin TSANG , Hao BAI , Yi JIN , Lei YU , NITTO DENKO CORPORATION
发明人： Kwok Yin Tsang , Hao Bai , Yi Jin , Lei Yu
IPC分类号： A61K47/48 , A61K31/337 , C08G73/02
CPC分类号： A61K47/645 , A61K31/337 , A61K47/595 , C08G69/10 , C08G69/46 , C08G69/48
摘要： Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.
摘要翻译： 本文描述的是降低聚阴离子聚合物缀合物的内毒素含量的方法。 特别地，本文描述了可以用于多种药物递送应用的聚阴离子聚合物缀合物中降低内毒素含量的方法。
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公开(公告)号：US09078926B2
公开(公告)日：2015-07-14
申请号：US13791137
申请日：2013-03-08
发明人： Seiji Nukui , Kwok Yin Tsang , Chunfeng Yin , Yi Jin , Lei Yu
IPC分类号： A61K31/045 , A61K31/337 , A61K31/40 , A61K38/02 , A61K47/34 , A61K47/48
CPC分类号： A61K47/48207 , A61K47/645
摘要： This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to polyglutamate amino acid conjugates that can include a linker to a compound that can include a drug, and their use for a variety of drug delivery applications, e.g., anticancer.
摘要翻译： 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可以包括可包含药物的化合物的连接体的聚谷氨酸氨基酸缀合物及其用于各种药物递送的用途 应用，例如抗癌。
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公开(公告)号：US20140212474A1
公开(公告)日：2014-07-31
申请号：US14167223
申请日：2014-01-29
发明人： Yoshiro Niitsu , Lei Yu , Gang Zhao , Sang Van , Fu Chen
CPC分类号： A61K47/34 , A61K9/127 , A61K31/00 , A61K31/337 , A61K31/7088 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/36 , A61K47/64
摘要： Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译： 可以包括载体，靶向剂和治疗剂的组合物在本文中公开。 治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。
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