公开(公告)号：US20190290596A1

公开(公告)日：2019-09-26

申请号：US16354275

申请日：2019-03-15

Applicant: NITTO DENKO CORPORATION

Inventor： Tomohito TAKITA ,  Kaiji FUJIWARA ,  Chie MATSUMOTO ,  Akinori SUGIYAMA ,  Jyun ISAYAMA ,  Toshinari HONDA ,  Ai FUNASAKI

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/385

Abstract: Provided are a production method of a pregabalin-containing composition, which suppresses crystallization of pregabalin, and a pregabalin-containing composition that shows suppressed crystallization of Pregabalin. The production method of the pregabalin-containing composition of the present invention contains steps of:(1) dissolving pregabalin in an aqueous solution of an acid to prepare an aqueous solution of a salt of pregabalin; (2) mixing the aqueous solution of pregabalin salt and a hydrophilic resin to prepare a mixture thereof; and (3) concentrating the mixture; wherein the acid has an acid dissociation constant lower than that of pregabalin.