公开(公告)号：US20200025443A1

公开(公告)日：2020-01-23

申请号：US16499482

申请日：2018-04-02

Applicant: NITTO DENKO CORPORATION

Inventor： Chie MATSUMOTO ,  Takao YOSHIKAWA ,  Takuya SHISHIDO ,  Yuji TOYOTA ,  Sachiko SAKAMOTO ,  Yoshimitsu SHIMOMURA ,  Mitsuhiko HORI

IPC: F26B5/04 ,  F26B5/06 ,  A23L3/54 ,  A23L3/44

Abstract: The present invention aims to provide a method and an apparatus for producing a lyophilized body, each of which can achieve energy saving, low cost, and a reduction in processing time and can provide a lyophilized body less damaged by a freezing process and a drying process. The present invention relates to a method for lyophilizing a substance using an electromagnetic wave, and the lyophilization method includes freezing the substance under irradiation of at least an electromagnetic wave and reduced-pressure drying the frozen substance under irradiation of at least an electromagnetic wave.

公开(公告)号：US20190231712A1

公开(公告)日：2019-08-01

申请号：US16262391

申请日：2019-01-30

Applicant: NITTO DENKO CORPORATION

Inventor： Chie MATSUMOTO ,  Tomohito TAKITA ,  Kaiji FUJIWARA ,  Akinori SUGIYAMA ,  Tomoya TANAKA

IPC: A61K9/70 ,  A61K47/12 ,  A61K47/18 ,  A61K31/197 ,  A61K47/32 ,  A61K47/38 ,  A61K47/36

CPC classification number: A61K9/7084 ,  A61K9/7023 ,  A61K31/197 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

Abstract: Provided is a transdermal absorption preparation having superior drug skin permeability, which can uniformly disperse the drug in the preparation and maintain the uniform dispersion state of the drug.A transdermal absorption preparation having a plaster layer containing a drug, a polymer and a pH adjuster, in which the aforementioned polymer contains a polymer having a particular glass transition temperature of 30° C.-200° C., and the surface of the plaster layer has a pH of 6.7-10.0.

公开(公告)号：US20160264825A1

公开(公告)日：2016-09-15

申请号：US15032131

申请日：2014-10-01

Applicant: NITTO DENKO CORPORATION

Inventor： Natsuki UKEI ,  Izumi NISHIMURA ,  Chie MATSUMOTO ,  Mika OKADA

IPC: C09J7/02

CPC classification number: C09J7/38 ,  C08K3/22 ,  C08K2003/2241 ,  C08L23/0815 ,  C09J7/22 ,  C09J7/243 ,  C09J123/12 ,  C09J133/08 ,  C09J2201/122 ,  C09J2201/606 ,  C09J2205/106 ,  C09J2423/006 ,  C09J2423/046 ,  C09J2423/106 ,  C09J2433/00 ,  C08F2220/1858 ,  C08F2220/1825 ,  C08F220/06 ,  C08F2216/1475

Abstract: Provided are a surface protection sheet with excellent weatherability, good anti-residue properties and low-contaminating properties and a water-dispersed PSA composition for surface protection sheets. The surface protection sheet provided by this invention comprises a PSA layer and a support substrate. The PSA layer is formed from a water-dispersed PSA composition comprising an acrylic polymer and a crosslinking agent. The acrylic polymer is obtained by emulsion polymerization of a starting monomer mixture comprising 50 to 99.9 wt % C1-20alkyl (meth)acrylate and 0.1 to 5 wt. % carboxy group-containing monomer. The crosslinking agent comprises one, two or more species selected from a group consisting of oxazoline-based crosslinking agents, isocyanate-based crosslinking agents and epoxy-based crosslinking agents. The support substrate comprises 50% by weight or more polyolefin resin and 5 to 30% by weight inorganic powder.

Abstract translation: 提供具有优异的耐候性，良好的抗残渣性和低污染性的表面保护片，以及​​用于表面保护片的水分散型PSA组合物。 本发明提供的表面保护片包括粘合剂层和支撑基底。 PSA层由包含丙烯酸类聚合物和交联剂的水分散型粘合剂组合物形成。 丙烯酸类聚合物通过包含50-99.9重量％（甲基）丙烯酸C 1-20烷基酯和0.1至5重量％的（甲基）丙烯酸酯的起始单体混合物的乳液聚合而获得。 ％含羧基单体。 交联剂包含选自基于恶唑啉的交联剂，异氰酸酯基交联剂和环氧基交联剂中的一种，两种或更多种。 支撑基材包含50重量％以上的聚烯烃树脂和5〜30重量％的无机粉末。

公开(公告)号：US20190290596A1

公开(公告)日：2019-09-26

申请号：US16354275

申请日：2019-03-15

Applicant: NITTO DENKO CORPORATION

Inventor： Tomohito TAKITA ,  Kaiji FUJIWARA ,  Chie MATSUMOTO ,  Akinori SUGIYAMA ,  Jyun ISAYAMA ,  Toshinari HONDA ,  Ai FUNASAKI

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/385

Abstract: Provided are a production method of a pregabalin-containing composition, which suppresses crystallization of pregabalin, and a pregabalin-containing composition that shows suppressed crystallization of Pregabalin. The production method of the pregabalin-containing composition of the present invention contains steps of:(1) dissolving pregabalin in an aqueous solution of an acid to prepare an aqueous solution of a salt of pregabalin; (2) mixing the aqueous solution of pregabalin salt and a hydrophilic resin to prepare a mixture thereof; and (3) concentrating the mixture; wherein the acid has an acid dissociation constant lower than that of pregabalin.

公开(公告)号：US20180311362A1

公开(公告)日：2018-11-01

申请号：US15935443

申请日：2018-03-26

Applicant: Nitto Denko Corporation

Inventor： Tomohito TAKITA ,  Kaiji FUJIWARA ,  Chie MATSUMOTO

IPC: A61K47/32 ,  A61K9/70 ,  A61K31/137 ,  A61K31/135

CPC classification number: A61K9/7061 ,  A61K9/7053 ,  A61K31/135 ,  A61K31/137

Abstract: Provided is a transdermal absorption preparation that shows superior skin permeability of a drug and that does not easily cause cold flow.A transdermal absorption preparation having a drug-containing layer containing a drug and a polymer, wherein 50-100 wt % of the polymer in the drug-containing layer is a polymer having a glass transition temperature of 30° C.-200° C., and the drug in the drug-containing layer is in an amorphous state.

公开(公告)号：US20160280967A1

公开(公告)日：2016-09-29

申请号：US15032138

申请日：2014-10-01

Applicant: NITTO DENKO CORPORATION

Inventor： Natsuki UKEI ,  Izumi NISHIMURA ,  Chie MATSUMOTO ,  Mika OKADA ,  Nobuaki MARUOKA

IPC: C09J7/02

CPC classification number: C09J123/22 ,  C08K5/29 ,  C08K5/353 ,  C09J7/22 ,  C09J7/38 ,  C09J133/06 ,  C09J133/08 ,  C09J2201/606 ,  C09J2201/622 ,  C09J2203/306 ,  C09J2205/102 ,  C09J2423/00 ,  C09J2423/046 ,  C09J2423/106 ,  C09J2433/00

Abstract: This invention provides a surface protection sheet that allows for easy application to an adherend surface with good removability. The surface protection sheet provided by this invention comprises a PSA layer and a support substrate supporting the PSA layer. The surface protection sheet has a peel strength (SA) after adhered to a stainless steel plate and stored at 23° C. for 30 minutes, and a peel strength (SB) after adhered on a stainless steel plate and stored at 70° C. for 168 hours, at a peel strength ratio (SB/SA) of 5 or less. The surface protection sheet has a peel strength to itself of 5 N/25 mm or less when the PSA layer is adhered to itself and peeled apart after one minute.

Abstract translation: 本发明提供了一种表面保护片，其允许容易地应用于具有良好可移除性的被粘物表面。 本发明提供的表面保护片包括粘合剂层和支撑粘合剂层的支撑基底。 表面保护片在粘附于不锈钢板上后的剥离强度（SA）在23℃下保存30分钟，剥离强度（SB）粘贴在不锈钢板上并在70℃下保存。 168小时，剥离强度比（SB / SA）为5以下。 当PSA层粘附到自身并在1分钟后剥离时，表面保护片的剥离强度本身为5N / 25mm或更小。