公开(公告)号：US20220380533A1

公开(公告)日：2022-12-01

申请号：US17763498

申请日：2020-09-25

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki Yoshioka ,  Ken Hamura ,  Kazuki Osakama ,  Nobuhiro Nishiyama

IPC: C08G65/333 ,  C08G83/00 ,  C07K5/103 ,  C07K14/46 ,  C07K7/06

Abstract: A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1): wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.

公开(公告)号：US20220339290A1

公开(公告)日：2022-10-27

申请号：US17763516

申请日：2020-09-25

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Ken Hamura ,  Hiroki Yoshioka ,  Kazuki Osakama ,  Nobuhiro Nishiyama

IPC: A61K47/64 ,  A61K47/60

Abstract: A branched degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A branched degradable polyethylene glycol derivative represented by the following formula (1), containing, in a molecule, an oligopeptide that is degraded in the cells: wherein k1 and k2 are each independently 1-12, j1 and j2 are each independently 45-950, R is a hydrogen atom, a substituted or unsubstituted alkyl group having 1-12 carbon atoms, a substituted aryl group, an aralkyl group or a heteroalkyl group, Z is an oligopeptide that is degraded by enzyme in the cells, X is a functional group capable of reacting with a bio-related substance, and L1 and L2 are each independently a single bond or a divalent spacer.