专利检索 ap:("NORTHWESTERN UNIVERSITY") AND inv:"Kaivvei Liang" 第 1 页

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发明申请
SMALL MOLECULES FOR DISRUPTING THE SUPER ELONGATION COMPLEX AND INHIBITING TRANSCRIPTION ELONGATION FOR CANCER THERAPY 有权

公开(公告)号：US20210094907A1

公开(公告)日：2021-04-01

申请号：US16981654

申请日：2019-03-21

申请人： NORTHWESTERN UNIVERSITY

发明人： Ali Shilatifard , Kaivvei Liang , Edwin R. Smith , Gary E. Schiitz , Rama K. Mishra , Kristen Stoltz

IPC分类号： C07C235/74 , C07C235/78 , C07D241/20 , C07D213/40 , C07D257/06 , C07D271/07 , C07D277/46 , C07D213/75 , C07D239/42 , C07D261/18 , C07D231/14 , C07D239/36 , A61P35/00

摘要： Disclosed are compounds which may be utilized to inhibit transcription by RNA Polymerase II (Pol II), and in particular to disrupt the Super Elongation Complex (SEC). The compounds may be utilized in pharmaceutical compositions and methods for treating diseases and disorders associated with the biological activity of SEC, and in particular, diseases and disorders that are associated with high levels of expression of genes whose expression is SEC-dependent and that promote, support, or otherwise are required for the disease or disorder such as cancers.