公开(公告)号：US10682316B2

公开(公告)日：2020-06-16

申请号：US15358743

申请日：2016-11-22

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith John Simons ,  Estelle Simons ,  Enrique Nieves

IPC: A61K31/137 ,  A61K9/19 ,  A61K9/00 ,  A61K9/14

Abstract: The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

公开(公告)号：US20140242177A1

公开(公告)日：2014-08-28

申请号：US14353118

申请日：2012-10-19

Applicant: Keith SIMONS ,  Estelle SIMONS ,  Ousama RACHID ,  NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Keith Simons ,  Estelle Simons ,  Ousama Rachid

IPC: A61K9/14 ,  A61K9/00 ,  A61K47/36 ,  A61K47/02 ,  A61K31/137 ,  A61K31/194

CPC classification number: A61K9/14 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/5115 ,  A61K9/5161 ,  A61K31/137 ,  A61K31/194 ,  A61K47/02 ,  A61K47/36

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

Abstract translation: 本发明提供了包括肾上腺素纳米颗粒的组合物和用于治疗使用该组合物治疗对肾上腺素如肾脏疾病如心脏事件或过敏反应特别是过敏反应的病症的方法。 肾上腺素纳米颗粒可以掺入到口腔崩解和快速崩解片剂药物制剂中，并且可以显着增加肾上腺素的舌下生物利用度，从而降低所需的肾上腺素剂量。 另外，本发明提供了用于制备用于所述组合物的稳定的肾上腺素纳米颗粒的方法。

公开(公告)号：US11246843B2

公开(公告)日：2022-02-15

申请号：US16377810

申请日：2019-04-08

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K31/137 ,  A61K9/20 ,  A61K9/00 ,  A61K9/14

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

公开(公告)号：US10251849B2

公开(公告)日：2019-04-09

申请号：US15262961

申请日：2016-09-12

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K31/137 ,  A61K9/00 ,  A61K9/20 ,  A61K9/14

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

公开(公告)号：US20150164827A1

公开(公告)日：2015-06-18

申请号：US14408038

申请日：2013-06-14

Applicant: Ousama RACHID ,  Keith SIMONS ,  Estelle SIMONS ,  NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K31/137 ,  A61K9/14 ,  A61K9/00

CPC classification number: A61K31/137 ,  A61K9/0056 ,  A61K9/14 ,  A61K9/2054

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

Abstract translation: 本发明提供包括肾上腺素纳米颗粒的组合物和用于治疗性使用该组合物用于治疗响应于肾上腺素（例如心脏事件或过敏反应，特别是过敏反应）的病症的组合物。 肾上腺素纳米颗粒可以掺入到口腔崩解和快速崩解片剂药物制剂中，并且可以显着增加肾上腺素的舌下生物利用度，从而降低所需的肾上腺素剂量。 另外，本发明提供了用于制备用于所述组合物的稳定的肾上腺素纳米颗粒的方法。

公开(公告)号：US10568836B2

公开(公告)日：2020-02-25

申请号：US15882399

申请日：2018-01-29

Applicant: Nova Southeastern University

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K9/14 ,  A61K31/137 ,  A61K9/00 ,  A61K31/194 ,  A61K47/02 ,  A61K47/36

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

公开(公告)号：US10159656B2

公开(公告)日：2018-12-25

申请号：US15288745

申请日：2016-10-07

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K31/00 ,  A61K9/00 ,  A61K31/137 ,  A61K9/14 ,  A61K47/12 ,  A61K47/26

Abstract: The invention provides compositions including epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.

公开(公告)号：US11229613B2

公开(公告)日：2022-01-25

申请号：US16225609

申请日：2018-12-19

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K9/56 ,  A61K31/137 ,  A61K9/00 ,  A61K9/14 ,  A61K31/00 ,  A61K47/12 ,  A61K47/26

Abstract: The invention provides compositions including epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.

公开(公告)号：US20180147145A1

公开(公告)日：2018-05-31

申请号：US15882399

申请日：2018-01-29

Applicant: Nova Southeastern University

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K9/14 ,  A61K47/36 ,  A61K9/00 ,  A61K31/137 ,  A61K47/02

CPC classification number: A61K9/14 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/5115 ,  A61K9/5161 ,  A61K31/137 ,  A61K31/194 ,  A61K47/02 ,  A61K47/36

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

公开(公告)号：US09877921B2

公开(公告)日：2018-01-30

申请号：US15266843

申请日：2016-09-15

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： Mutasem Rawas-Qalaji ,  Ousama Rachid ,  Keith Simons ,  Estelle Simons

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/00 ,  A61K31/137 ,  A61K47/36 ,  A61K47/02

CPC classification number: A61K31/137 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/5161

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.