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公开(公告)号:US20230053449A1
公开(公告)日:2023-02-23
申请号:US17289058
申请日:2019-10-30
Applicant: NOVARTIS AG
Inventor: Lisa BARNETT , Steven BENDER , Alex Cortez , Sarah COX , Jonathan DEANE , Scott Martin GLASER , Ben WEN , Tom Yao-Hsiang WU
Abstract: Provided herein are antibodies to DC-SIGN, conjugates of DC-SiGN antibodies, and DC-SiGN antibody fusion proteins and the use of such antibodies, conjugates, and fusion proteins for the treatment of diseases such as cancer.
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公开(公告)号:US20200164084A1
公开(公告)日:2020-05-28
申请号:US16608608
申请日:2018-04-27
Applicant: NOVARTIS AG
Inventor: Alex Cortez , Bernhard Hubert Geierstanger , Rodrigo Andreas Hess , Timothy Z. Hoffman , Shailaja Kasibhatla , Tetsuo Uno , Xing Wang , Tom Yao-Hsiang Wu
IPC: A61K47/68 , A61K39/395 , A61K9/00 , A61P35/00 , A61K31/519 , A61K39/00
Abstract: Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies. In some embodiments, the conjugates are used in combination with a second therapeutic agent.
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公开(公告)号:US10407431B2
公开(公告)日:2019-09-10
申请号:US15906424
申请日:2018-02-27
Applicant: NOVARTIS AG
Inventor: Alex Cortez , Timothy Hoffman , Yongkai Li , Tom Yao-Hsiang Wu , Xiaoyue Zhang
IPC: A61K31/519 , A61P11/06 , A61P19/02 , A61P35/04 , A61P37/06 , A61P25/28 , C07D487/04
Abstract: The invention provides compounds of Formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.
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