公开(公告)号：US20230053449A1

公开(公告)日：2023-02-23

申请号：US17289058

申请日：2019-10-30

Applicant: NOVARTIS AG

Inventor： Lisa BARNETT ,  Steven BENDER ,  Alex Cortez ,  Sarah COX ,  Jonathan DEANE ,  Scott Martin GLASER ,  Ben WEN ,  Tom Yao-Hsiang WU

IPC: A61K47/68 ,  C07K16/28 ,  A61P35/00

Abstract: Provided herein are antibodies to DC-SIGN, conjugates of DC-SiGN antibodies, and DC-SiGN antibody fusion proteins and the use of such antibodies, conjugates, and fusion proteins for the treatment of diseases such as cancer.

公开(公告)号：US20200164084A1

公开(公告)日：2020-05-28

申请号：US16608608

申请日：2018-04-27

Applicant: NOVARTIS AG

Inventor： Alex Cortez ,  Bernhard Hubert Geierstanger ,  Rodrigo Andreas Hess ,  Timothy Z. Hoffman ,  Shailaja Kasibhatla ,  Tetsuo Uno ,  Xing Wang ,  Tom Yao-Hsiang Wu

IPC: A61K47/68 ,  A61K39/395 ,  A61K9/00 ,  A61P35/00 ,  A61K31/519 ,  A61K39/00

Abstract: Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies. In some embodiments, the conjugates are used in combination with a second therapeutic agent.

公开(公告)号：US10407431B2

公开(公告)日：2019-09-10

申请号：US15906424

申请日：2018-02-27

Applicant: NOVARTIS AG

Inventor： Alex Cortez ,  Timothy Hoffman ,  Yongkai Li ,  Tom Yao-Hsiang Wu ,  Xiaoyue Zhang

IPC: A61K31/519 ,  A61P11/06 ,  A61P19/02 ,  A61P35/04 ,  A61P37/06 ,  A61P25/28 ,  C07D487/04

Abstract: The invention provides compounds of Formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.