公开(公告)号：US11524998B2

公开(公告)日：2022-12-13

申请号：US17375860

申请日：2021-07-14

Applicant: NOVARTIS AG

Inventor： Chad Eric Bigelow ,  Ana Maria Carrion ,  James Edgar Chastain ,  Kirk Lee Clark ,  Bijan Alexandre Etemad-Gilbertson ,  Joy Gispati Ghosh ,  Shawn Michael Hanks ,  Nicole Haubst ,  Ganesh Rajan Iyer ,  Nina Moker ,  Andrew Anh Nguyen ,  Stephen Hedrick Poor ,  Yubin Qiu ,  Nalini Velamur Rangaswamy ,  Michael Stefanidakis ,  Engin Toksoz ,  Michael Zbigniew Twarog

IPC: C07K16/22 ,  A61P27/02 ,  C07K16/46 ,  A61K39/00

Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.