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公开(公告)号：US09051365B2
公开(公告)日：2015-06-09
申请号：US13716526
申请日：2012-12-17
Applicant: NOVARTIS AG
Inventor： Leslie Ngozi Anuna Johnson , Ute Jaeger , Yong-In Kim , Christian Carsten Silvester Kunz , Igor Splawski , Michael Roguska , Joy Ghosh , Barbara Brannetti , Sha-Mei Liao , Michael Stefanidakis
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6863
Abstract: The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5).
Abstract translation: 本发明涉及结合补体因子P并用于其的抗体或其抗原结合片段，以及抗因子P抗体与结合补体成分5（C5）的抗体或其抗原结合片段的组合。
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公开(公告)号：US11524998B2
公开(公告)日：2022-12-13
申请号：US17375860
申请日：2021-07-14
Applicant: NOVARTIS AG
Inventor： Chad Eric Bigelow , Ana Maria Carrion , James Edgar Chastain , Kirk Lee Clark , Bijan Alexandre Etemad-Gilbertson , Joy Gispati Ghosh , Shawn Michael Hanks , Nicole Haubst , Ganesh Rajan Iyer , Nina Moker , Andrew Anh Nguyen , Stephen Hedrick Poor , Yubin Qiu , Nalini Velamur Rangaswamy , Michael Stefanidakis , Engin Toksoz , Michael Zbigniew Twarog
Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
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公开(公告)号：US09988440B2
公开(公告)日：2018-06-05
申请号：US14309330
申请日：2014-06-19
Applicant: NOVARTIS AG
Inventor： Leslie Ngozi Anuna Johnson , Ute Jaeger , Yong-In Kim , Christian Carsten Silvester Kunz , Igor Splawski , Michael Roguska , Joy Ghosh , Barbara Brannetti , Michael Stefanidakis , Sha-Mei Liao
IPC: A61K39/395 , C07K16/18 , G01N33/68 , C07K16/24 , A61K39/00
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6863
Abstract: The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5).
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