公开(公告)号：US20220332821A1

公开(公告)日：2022-10-20

申请号：US17620987

申请日：2020-06-22

Applicant: NOVARTIS AG

Inventor： Kimberly AARDALEN ,  Aida ABUJOUB ,  John BLANKENSHIP ,  Anuradha CONNOR ,  Mirek DOSTALEK ,  Tony FLEMING ,  Brian HOLMBERG ,  Connie HONG ,  Lu HUANG ,  Haihui LU ,  K. Gary J. VANASSE

IPC: C07K16/28 ,  A61P35/00 ,  A61K9/00 ,  A61K31/167 ,  A61K31/417 ,  A61K31/56

Abstract: The present disclosure relates to dosing regimens, formulations, and combinations comprising a multispecific antibody having at least binding specificity towards B cell maturation antigen (BCMA) and a T-cell engaging arm; and methods of using such multispecific antibodies in the treatment or prevention of disease, such as, cancer.