公开(公告)号：US20230057071A1

公开(公告)日：2023-02-23

申请号：US17786717

申请日：2020-12-03

Applicant: NOVARTIS AG

Inventor： K. Gary J. VANASSE ,  Haiying SUN ,  Mirek DOSTALEK ,  Mikael RINNE ,  Anshu MARATHE ,  Luigi MANENTI ,  Claire FABRE ,  Fariba KHANSHAN

IPC: C07K16/22 ,  C07K16/28 ,  C07K16/24 ,  A61K31/706 ,  A61P35/00

Abstract: Combination therapies comprising TIM-3 inhibitors and TGF-β inhibitors are disclosed. The combinations can be used to treat or prevent cancerous conditions and disorders, including myelofibrosis or myelodysplastic syndrome.

公开(公告)号：US20220332821A1

公开(公告)日：2022-10-20

申请号：US17620987

申请日：2020-06-22

Applicant: NOVARTIS AG

Inventor： Kimberly AARDALEN ,  Aida ABUJOUB ,  John BLANKENSHIP ,  Anuradha CONNOR ,  Mirek DOSTALEK ,  Tony FLEMING ,  Brian HOLMBERG ,  Connie HONG ,  Lu HUANG ,  Haihui LU ,  K. Gary J. VANASSE

IPC: C07K16/28 ,  A61P35/00 ,  A61K9/00 ,  A61K31/167 ,  A61K31/417 ,  A61K31/56

Abstract: The present disclosure relates to dosing regimens, formulations, and combinations comprising a multispecific antibody having at least binding specificity towards B cell maturation antigen (BCMA) and a T-cell engaging arm; and methods of using such multispecific antibodies in the treatment or prevention of disease, such as, cancer.

公开(公告)号：US20230056470A1

公开(公告)日：2023-02-23

申请号：US17786265

申请日：2020-12-03

Applicant: NOVARTIS AG

Inventor： Mirek DOSTALEK ,  Claire FABRE ,  Fariba KHANSHAN

IPC: C07K16/22 ,  C07K16/28 ,  A61P35/00 ,  A61K45/06 ,  A61K39/395

Abstract: Therapies using TGF-β inhibitors and/or PD-1 inhibitors are disclosed. These drugs at certain doses (including flat dosing) and regimens can be used to treat or prevent proliferative diseases such as solid tumors, including pancreatic cancers. Further combination and uses thereof are also disclosed.