公开(公告)号：US11229643B2

公开(公告)日：2022-01-25

申请号：US16347194

申请日：2017-11-01

Applicant: NOVARTIS AG

Inventor： Robin Alec Fairhurst ,  Diana Graus Porta ,  Jacqueline Kinyamu-Akunda ,  Andreas Joerg Mahl ,  Luigi Manenti ,  Andreas Weiss ,  Armin Wolf ,  Kuno Wuersch

IPC: A61K31/496 ,  A61K31/14

Abstract: The present invention relates to a pharmaceutical combination comprising an FGFR4 inhibitor and a bile acid sequestrant, to the use of the pharmaceutical combination in the treatment of cancer, to the use of a bile acid sequestrant to reduce or mitigate side-effects associated with FGFR4 inhibition therapy.