公开(公告)号：US20180086716A1

公开(公告)日：2018-03-29

申请号：US15711984

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry BURSULAYA ,  Andreas FISCH ,  James Paul LAJINESS ,  Rainer MACHAUER ,  Swapnil MALEKAR ,  Hank Michael James PETRASSI ,  Farshad RAMAZANI ,  Anne-Catherine REMOND ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Eric VANGREVELINGHE

IPC: C07D231/56 ,  A61K9/16 ,  A61K9/00 ,  C07D403/12 ,  A61K31/416 ,  C07D401/12 ,  A61K31/454 ,  C07D405/12

CPC classification number: C07D231/56 ,  A61K9/0019 ,  A61K9/1647 ,  A61K31/416 ,  A61K31/454 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20210188842A1

公开(公告)日：2021-06-24

申请号：US16941395

申请日：2020-07-28

Applicant: NOVARTIS AG

Inventor： Badry BURSULAYA ,  Andreas FISCH ,  James Paul LAJINESS ,  Rainer MACHAUER ,  Swapnil MALEKAR ,  Hank Michael James PETRASSI ,  Farshad RAMAZANI ,  Anne-Catherine REMOND ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Eric VANGREVELINGHE

IPC: C07D471/04 ,  A61P21/00 ,  A61K9/00 ,  A61K9/50 ,  A61K31/437 ,  A61K31/496 ,  A61K31/538

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20190300522A1

公开(公告)日：2019-10-03

申请号：US16335496

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry BURSULAYA ,  Andreas FISCH ,  James Paul LAJINESS ,  Rainer MACHAUER ,  Swapnil MALEKAR ,  Hank Michael James PETRASSI ,  Farshad RAMAZANI ,  Anne-Catherine REMOND ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Eric VANGREVELINGHE

IPC: C07D471/04 ,  A61K9/00 ,  A61K9/50 ,  A61P21/00 ,  A61K31/437 ,  A61K31/538 ,  A61K31/496

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.