公开(公告)号：US20180140582A1

公开(公告)日：2018-05-24

申请号：US15876619

申请日：2018-01-22

Applicant: NOVARTIS AG

Inventor： Jun CAO ,  Bernhard ERB ,  Robin Alec FAIRHURST ,  Arnaud GRANDEURY ,  Shinji HATAKEYAMA ,  Magdalena KOZICZAK-HOLBRO ,  Xinzhong LAI ,  Philipp LUSTENBERGER ,  Bernd Ulrich RIEBESEHL ,  Nicola TUFILLI ,  Thomas ULLRICH ,  Xiang WU ,  Jianguang ZHOU

IPC: A61K31/428 ,  C07C53/10 ,  C07D277/68 ,  A61K45/06 ,  A61K31/167

CPC classification number: A61K31/428 ,  A61K31/167 ,  A61K45/06 ,  C07B2200/07 ,  C07C53/10 ,  C07D277/68 ,  Y02P20/55

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

公开(公告)号：US20210155606A1

公开(公告)日：2021-05-27

申请号：US17170690

申请日：2021-02-08

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D405/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (1) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20180086716A1

公开(公告)日：2018-03-29

申请号：US15711984

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry BURSULAYA ,  Andreas FISCH ,  James Paul LAJINESS ,  Rainer MACHAUER ,  Swapnil MALEKAR ,  Hank Michael James PETRASSI ,  Farshad RAMAZANI ,  Anne-Catherine REMOND ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Eric VANGREVELINGHE

IPC: C07D231/56 ,  A61K9/16 ,  A61K9/00 ,  C07D403/12 ,  A61K31/416 ,  C07D401/12 ,  A61K31/454 ,  C07D405/12

CPC classification number: C07D231/56 ,  A61K9/0019 ,  A61K9/1647 ,  A61K31/416 ,  A61K31/454 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20210188842A1

公开(公告)日：2021-06-24

申请号：US16941395

申请日：2020-07-28

Applicant: NOVARTIS AG

Inventor： Badry BURSULAYA ,  Andreas FISCH ,  James Paul LAJINESS ,  Rainer MACHAUER ,  Swapnil MALEKAR ,  Hank Michael James PETRASSI ,  Farshad RAMAZANI ,  Anne-Catherine REMOND ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Eric VANGREVELINGHE

IPC: C07D471/04 ,  A61P21/00 ,  A61K9/00 ,  A61K9/50 ,  A61K31/437 ,  A61K31/496 ,  A61K31/538

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20200299265A1

公开(公告)日：2020-09-24

申请号：US16884666

申请日：2020-05-27

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D405/14 ,  C07D401/10 ,  C07D401/12 ,  C07D409/14 ,  C07D213/82 ,  C07D411/14 ,  C07D491/107 ,  A61P19/00 ,  C07D417/00 ,  C07D413/00 ,  C07D419/00 ,  A61P19/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/20

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20190300522A1

公开(公告)日：2019-10-03

申请号：US16335496

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry BURSULAYA ,  Andreas FISCH ,  James Paul LAJINESS ,  Rainer MACHAUER ,  Swapnil MALEKAR ,  Hank Michael James PETRASSI ,  Farshad RAMAZANI ,  Anne-Catherine REMOND ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Eric VANGREVELINGHE

IPC: C07D471/04 ,  A61K9/00 ,  A61K9/50 ,  A61P21/00 ,  A61K31/437 ,  A61K31/538 ,  A61K31/496

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20190161474A1

公开(公告)日：2019-05-30

申请号：US16318250

申请日：2017-07-18

Applicant: NOVARTIS AG

Inventor： Luca ARISTA ,  Sreehari BABU ,  Jianwei BIAN ,  Kai CUI ,  Michael Patrick DILLON ,  Rene LATTMANN ,  Jialiang LI ,  Lv LIAO ,  Dimitrios LIZOS ,  Rita RAMOS ,  Nikolaus Johannes STIEFL ,  Thomas ULLRICH ,  Peggy USSELMANN ,  Xiaoyang WANG ,  Liladhar Murlidhar WAYKOLE ,  Sven WEILER ,  Yubo ZHANG ,  Yizong ZHOU ,  Tingying ZHU

IPC: C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D491/20 ,  C07D405/14 ,  C07D409/14 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  A61P19/08

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

公开(公告)号：US20150299120A1

公开(公告)日：2015-10-22

申请号：US14382073

申请日：2013-03-01

Applicant: NOVARTIS AG

Inventor： Mark Gary BOCK ,  Chetan PANDIT ,  Sanjita SASMAL ,  Thomas ULLRICH

IPC: C07D209/54 ,  C07D263/52 ,  A61K31/423 ,  C07D413/06 ,  C07D405/06 ,  C07D401/06 ,  A61K31/4439 ,  C07D491/107 ,  A61K31/4188 ,  A61K31/4184 ,  A61K31/422

CPC classification number: C07D209/54 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4439 ,  C07D233/72 ,  C07D235/02 ,  C07D263/44 ,  C07D263/52 ,  C07D401/06 ,  C07D405/06 ,  C07D413/06 ,  C07D491/107

Abstract: The present invention relates to a compound of formula (I-1) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 本发明涉及游离形式或药学上可接受的盐形式的式（I-1）化合物，其中取代基如说明书中所定义; 用于其制备，用作药物和包含它的药物。 本发明还提供药理活性剂和药物组合物的组合。