公开(公告)号：US10751417B2

公开(公告)日：2020-08-25

申请号：US15957474

申请日：2018-04-19

Applicant: NOVARTIS AG

Inventor： Christopher M. Adams ,  Myriam April ,  Tanzina Fazal ,  Cornelia Jutta Forster ,  Edward Charles Hall ,  Cameron Chuck-munn Lee

IPC: A61K47/36 ,  A61K47/61 ,  A61K47/69 ,  A61P27/02 ,  A61K9/00 ,  A61K31/496 ,  A61K47/10 ,  A61K47/22

Abstract: Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.

公开(公告)号：US10550102B2

公开(公告)日：2020-02-04

申请号：US16216420

申请日：2018-12-11

Applicant: NOVARTIS AG

Inventor： Christopher M. Adams ,  Doug Bevan ,  Michael Paul Capparelli ,  Takeru Ehara ,  Luciana Ferrara ,  Nan Ji ,  Erik Meredith ,  Muneto Mogi ,  James J. Powers ,  Ganesh Prasanna ,  Nello Mainolfi ,  Mitsunori Kato

IPC: C07D401/14 ,  C07D413/14 ,  C07D401/10 ,  C07D401/12 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  C07D405/14 ,  C07D401/04

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.