公开(公告)号：US10550102B2

公开(公告)日：2020-02-04

申请号：US16216420

申请日：2018-12-11

Applicant: NOVARTIS AG

Inventor： Christopher M. Adams ,  Doug Bevan ,  Michael Paul Capparelli ,  Takeru Ehara ,  Luciana Ferrara ,  Nan Ji ,  Erik Meredith ,  Muneto Mogi ,  James J. Powers ,  Ganesh Prasanna ,  Nello Mainolfi ,  Mitsunori Kato

IPC: C07D401/14 ,  C07D413/14 ,  C07D401/10 ,  C07D401/12 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  C07D405/14 ,  C07D401/04

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.