公开(公告)号：US20140275089A1

公开(公告)日：2014-09-18

申请号：US14350577

申请日：2012-10-11

Applicant: NOVARTIS AG

Inventor： Xizhong Huang ,  Cornelia Quadt ,  Hui-Qin Wang ,  Christine Fritsch ,  Christian René Schnell

IPC: A61K31/5377 ,  A61K31/4439

CPC classification number: A61K31/5377 ,  A61K31/16 ,  A61K31/235 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical combination comprising a 2-carboxamide cycloamino urea derivative compound of formula (I) and inhibitors of Heat Shock Protein 90, and the uses of such combinations in the treatment of proliferative diseases, more specifically PI3K dependent diseases, more specifically PI3K-alpha dependent diseases.

Abstract translation: 本发明涉及包含式（I）的2-甲酰胺环氨基脲衍生物化合物和热休克蛋白90抑制剂的药物组合，以及这些组合在治疗增殖性疾病中的用途，更具体地说是PI3K依赖性疾病 特别是PI3K-α依赖性疾病。

公开(公告)号：US20130045983A1

公开(公告)日：2013-02-21

申请号：US13655613

申请日：2012-10-19

Applicant: Novartis AG

Inventor： Carlos Garcia Echeverria ,  Michael Rugaard Jensen ,  Cornelia Quadt

IPC: A61K31/519 ,  C07D471/04 ,  A61P7/00 ,  A61P35/00 ,  A61P17/06

CPC classification number: A61K31/00 ,  A61K31/519

Abstract: The use of a Hsp90 inhibitor for the treatment of cancer of the bladder, the colon, the liver, the lung, the breast, the vagina, the ovaries, the pancreas, the kidney, the stomach, the gastrointestinal tract, the prostate, the head and neck, the peritoneal cavity, the thyroid, the bone, the brain, the central nervous system and/or the blood and/or for the treatment of myelodysplastic syndrome, systemic mastocytosis, von Hippel-Lindau syndrome, multicentric Castleman disease and/or psoriasis.

Abstract translation: 使用Hsp90抑制剂治疗膀胱癌，结肠癌，肝癌，肺癌，乳腺癌，阴道癌，卵巢癌，胰腺癌，肾癌，胃癌，胃肠道癌，前列腺癌， 腹膜腔，甲状腺，骨骼，脑，中枢神经系统和/或血液和/或治疗骨髓增生异常综合征，系统性肥大细胞增多症，von Hippel-Lindau综合征，多中心Castleman病和/ 或牛皮癣。