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![Pharmaceutical combination comprising co-administration of taxane and N-(1-cyclohexyl-2-{2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide or pharmaceutically acceptable salt(s) thereof](/abs-image/US/2014/12/09/US08906936B2/abs.jpg.150x150.jpg)
1.发明授权Pharmaceutical combination comprising co-administration of taxane and N-(1-cyclohexyl-2-{2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide or pharmaceutically acceptable salt(s) thereof 有权药物组合包括联合给予紫杉烷和N-（1-环己基-2- {2- [4-（4-氟 - 苯甲酰基） - 噻唑-2-基] - 吡咯烷-1-基} -2-氧代 - 乙基）-2-甲基氨基 - 丙酰胺或其药学上可接受的盐公开(公告)号：US08906936B2
公开(公告)日：2014-12-09
申请号：US13761634
申请日：2013-02-07
Applicant: Novartis AG
Inventor： Michael Rugaard Jensen , Christopher Sean Straub , Leigh Zawel , Mary Ann Tran , Youzhen Wang
IPC: A01N43/42 , A61K31/44 , A61K31/16 , A61K31/425 , A61K45/06 , A61K31/437 , A61K31/475 , C07D471/04 , A61K31/337
CPC classification number: A61K31/437 , A61K31/16 , A61K31/337 , A61K31/425 , A61K31/475 , A61K45/06 , C07D471/04 , A61K2300/00
Abstract: The invention provides a pharmaceutical combination comprising: a) compounds that inhibit the binding of the Smac protein to IAPs; and b) a taxane, and a method for treating or preventing a proliferative disease using such a combination.
Abstract translation: 本发明提供药物组合，其包含：a）抑制Smac蛋白与IAP结合的化合物; 和b）紫杉烷类，以及使用这种组合治疗或预防增殖性疾病的方法。
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![PHARMACEUTICAL COMBINATIONS COMPRISING A PYRIDO [4,3-D] PYRIMIDINE DERIVED HSP90-INHIBITOR AND A HER2 INHIBITOR](/abs-image/US/2014/11/06/US20140328834A1/abs.jpg.150x150.jpg)
2.发明申请PHARMACEUTICAL COMBINATIONS COMPRISING A PYRIDO [4,3-D] PYRIMIDINE DERIVED HSP90-INHIBITOR AND A HER2 INHIBITOR 审中-公开包含吡啶[4,3-D]吡啶衍生的HSP90-抑制剂和HER2抑制剂的药物组合公开(公告)号：US20140328834A1
公开(公告)日：2014-11-06
申请号：US14284240
申请日：2014-05-21
Applicant: NOVARTIS AG
Inventor： Carlos Garcia-Echeverria , Michael Rugaard Jensen
IPC: A61K31/5377 , A61K39/395
CPC classification number: A61K31/5377 , A61K31/395 , A61K31/519 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/76 , A61K2300/00
Abstract: A pharmaceutical combination comprising an Hsp90 inhibitor and an HER2 inhibitor, and methods of using the combination to treat proliferative disorders.
Abstract translation: 包含Hsp90抑制剂和HER2抑制剂的药物组合物，以及使用该组合治疗增殖性疾病的方法。
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公开(公告)号：US20130217719A1
公开(公告)日：2013-08-22
申请号：US13761634
申请日：2013-02-07
Applicant: Novartis AG
Inventor： Michael Rugaard Jensen , Christopher Sean Straub , Leigh Zawel , Mary Ann Tran , Youzhen Wang
IPC: A61K31/437 , A61K31/337 , C07D471/04
CPC classification number: A61K31/437 , A61K31/16 , A61K31/337 , A61K31/425 , A61K31/475 , A61K45/06 , C07D471/04 , A61K2300/00
Abstract: The invention provides a pharmaceutical combination comprising: a) compounds that inhibit the binding of the Smac protein to IAPs; and b) a taxane, and a method for treating or preventing a proliferative disease using such a combination.
Abstract translation: 本发明提供药物组合，其包含：a）抑制Smac蛋白与IAP结合的化合物; 和b）紫杉烷类，以及使用这种组合治疗或预防增殖性疾病的方法。
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公开(公告)号：US20130045983A1
公开(公告)日：2013-02-21
申请号：US13655613
申请日：2012-10-19
Applicant: Novartis AG
Inventor： Carlos Garcia Echeverria , Michael Rugaard Jensen , Cornelia Quadt
IPC: A61K31/519 , C07D471/04 , A61P7/00 , A61P35/00 , A61P17/06
CPC classification number: A61K31/00 , A61K31/519
Abstract: The use of a Hsp90 inhibitor for the treatment of cancer of the bladder, the colon, the liver, the lung, the breast, the vagina, the ovaries, the pancreas, the kidney, the stomach, the gastrointestinal tract, the prostate, the head and neck, the peritoneal cavity, the thyroid, the bone, the brain, the central nervous system and/or the blood and/or for the treatment of myelodysplastic syndrome, systemic mastocytosis, von Hippel-Lindau syndrome, multicentric Castleman disease and/or psoriasis.
Abstract translation: 使用Hsp90抑制剂治疗膀胱癌，结肠癌，肝癌，肺癌，乳腺癌，阴道癌，卵巢癌，胰腺癌，肾癌，胃癌，胃肠道癌，前列腺癌， 腹膜腔，甲状腺，骨骼，脑，中枢神经系统和/或血液和/或治疗骨髓增生异常综合征，系统性肥大细胞增多症，von Hippel-Lindau综合征，多中心Castleman病和/ 或牛皮癣。
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