公开(公告)号：US12221481B2

公开(公告)日：2025-02-11

申请号：US16877878

申请日：2020-05-19

Applicant: Novartis AG

Inventor： Brian Granda ,  Amy Rayo ,  Connie Hong ,  Dattananda Chelur ,  Haihui Lu ,  Regis Cebe ,  Sunyoung Jang

IPC: C07K16/30 ,  A61P35/00 ,  C07K14/47 ,  C07K16/28 ,  C12N15/63 ,  A61K39/00

Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

公开(公告)号：US12037378B2

公开(公告)日：2024-07-16

申请号：US17612993

申请日：2020-05-19

Applicant: NOVARTIS AG

Inventor： Barbara Brannetti ,  Dattananda Chelur ,  Brian Granda ,  Connie Hong

IPC: C07K14/705

CPC classification number: C07K14/70528

Abstract: The present disclosure provides CD2 binding molecules that specifically bind to CD2, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD2 binding molecules, and pharmaceutical compositions comprising the CD2 binding molecules and the conjugates. The disclosure further provides methods of using the CD2 binding molecules to modulate CD2 signaling in order to treat a variety of immune (e.g., autoimmune), inflammatory and proliferative disorders. The disclosure yet further provides recombinant host cells engineered to express the CD2 binding molecules and methods of producing the CD2 binding molecules by culturing the host cells under conditions in which the CD2 binding molecules are expressed.

公开(公告)号：US20210139585A1

公开(公告)日：2021-05-13

申请号：US16877878

申请日：2020-05-19

Applicant: Novartis AG

Inventor： Brian Granda ,  Amy Rayo ,  Connie Hong ,  Dattananda Chelur ,  Haihui Lu ,  Regis Cebe ,  Sunyoung Jang

IPC: C07K16/28 ,  C07K14/47 ,  C12N15/63 ,  A61P35/00

Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.