公开(公告)号：US20190119254A1

公开(公告)日：2019-04-25

申请号：US16216420

申请日：2018-12-11

Applicant: NOVARTIS AG

Inventor： Christopher M. ADAMS ,  Doug BEVAN ,  Michael Paul CAPPARELLI ,  Takeru EHARA ,  Luciana FERRARA ,  Nan Ji ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA ,  Nello MAINOLFI ,  Mitsunori KATO

IPC: C07D401/14 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4725 ,  A61K9/00 ,  C07D413/14 ,  A61K31/454 ,  C07D401/12 ,  C07D401/10 ,  A61K31/4439

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.