公开(公告)号：US20250090699A1

公开(公告)日：2025-03-20

申请号：US18802972

申请日：2024-08-13

Applicant: Novartis AG

Inventor： Salvatore BONGARZONE ,  Davide CAMPORESE ,  Gonçalo dos Santos CLEMENTE ,  Takeru EHARA ,  Matteo FISCHER ,  Andrei Alexandrovich GOLOSOV ,  Philipp GROSCHE ,  Philipp HOLZER ,  Alexei KARPOV ,  Marion LACAUD-BAUMLIN ,  Lukas LEDER ,  Rafael Bermeo MALO ,  Andreas MARZINZIK ,  Yoshihide MIZUKOSHI ,  Charlie MUNSCH ,  Markus Oliver RESCHKE ,  Holger SELLNER ,  Therese-Marie STACHYRA

IPC: A61K51/08 ,  A61P35/00 ,  C07B59/00

Abstract: Described herein are cyclic peptides targeting fibroblast activation protein (FAP), and their incorporation into compounds for radioligand imaging and therapies, as well as methods and/or uses of such compounds for the imaging, treatment and/or prevention of FAP-implicated diseases and disorders.

公开(公告)号：US20190119254A1

公开(公告)日：2019-04-25

申请号：US16216420

申请日：2018-12-11

Applicant: NOVARTIS AG

Inventor： Christopher M. ADAMS ,  Doug BEVAN ,  Michael Paul CAPPARELLI ,  Takeru EHARA ,  Luciana FERRARA ,  Nan Ji ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA ,  Nello MAINOLFI ,  Mitsunori KATO

IPC: C07D401/14 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4725 ,  A61K9/00 ,  C07D413/14 ,  A61K31/454 ,  C07D401/12 ,  C07D401/10 ,  A61K31/4439

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20190002438A1

公开(公告)日：2019-01-03

申请号：US16063059

申请日：2016-12-16

Applicant: NOVARTIS AG

Inventor： Christopher ADAMS ,  Takeru EHARA

IPC: C07D401/14 ,  C07D401/12 ,  C07D401/10 ,  A61P27/06

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.