公开(公告)号：US20250092016A1

公开(公告)日：2025-03-20

申请号：US18580986

申请日：2022-07-20

Applicant: NOVARTIS AG

Inventor： Denghui BAO ,  Fengfeng GUO ,  Matthew James HESSE ,  Viktor HORNAK ,  Sajan JOSEPH ,  Thomas Martin KIRRANE, JR. ,  Haiyao LIN ,  Bo LIU ,  Yanan MIAO ,  Heinz Ernst MOSER ,  Julien PAPILLON ,  Yang QU ,  Lei SHI ,  Jun YUAN ,  Teng ZHANG

IPC: C07D401/14 ,  A61K31/4725 ,  A61K31/501 ,  A61K31/506 ,  A61P31/14 ,  C07D401/04

Abstract: Provided herein are compounds and compositions for treating, managing or preventing coronaviral related diseases. In particular, provided herein are compounds which are inhibitors of SARS-CoV-2 main protease (Mpro), pharmaceutical compositions comprising such compounds, method for synthesizing such compounds and methods of using such compounds and compositions for the treatment, management or prevention of coronaviral related diseases.