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公开(公告)号:US20180127436A1
公开(公告)日:2018-05-10
申请号:US15807462
申请日:2017-11-08
申请人: NOVARTIS AG
发明人: Jian DING , Marie-Helene LARRAUFIE , Deborah ROTHMAN , Nik SAVAGE , Shaowen WANG
IPC分类号: C07D498/18 , A61K31/436
CPC分类号: C07D498/18 , A61K31/436 , A61K31/453 , A61K45/06 , C07D498/08
摘要: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.
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公开(公告)号:US20220315582A1
公开(公告)日:2022-10-06
申请号:US16973836
申请日:2020-07-31
申请人: Novartis AG
发明人: Chris ADAIR , Tracy CHEN , Jian DING , Christy FRYER , Yuko ISOME , Marie-Helene LARRAUFIE , Katsumasa NAKAJIMA , Nik SAVAGE , Ariel Sterling TWOMEY
IPC分类号: C07D471/10 , A61P35/00
摘要: The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.
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公开(公告)号:US20190194227A1
公开(公告)日:2019-06-27
申请号:US16286002
申请日:2019-02-26
申请人: NOVARTIS AG
发明人: Jian DING , Marie-Helene LARRAUFIE , Deborah ROTHMAN , Nik SAVAGE , Shaowen WANG
IPC分类号: C07D498/18 , A61K31/453 , C07D498/08 , A61K31/436 , A61K45/06
CPC分类号: C07D498/18 , A61K31/436 , A61K31/453 , A61K45/06 , C07D498/08
摘要: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.
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