公开(公告)号：US20240262827A1

公开(公告)日：2024-08-08

申请号：US18594323

申请日：2024-03-04

Applicant: NOVARTIS AG

Inventor： Chris ADAIR ,  Tracy CHEN ,  Jian DING ,  Christy FRYER ,  Yuko ISOME ,  Marie-Helene LARRAUFIE ,  Katsumasa NAKAJIMA ,  Nik SAVAGE ,  Ariel Sterling TWOMEY

IPC: C07D471/10 ,  A61K31/4747 ,  A61P35/00

CPC classification number: C07D471/10 ,  A61P35/00 ,  A61K31/4747

Abstract: The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

公开(公告)号：US20180127436A1

公开(公告)日：2018-05-10

申请号：US15807462

申请日：2017-11-08

Applicant: NOVARTIS AG

Inventor： Jian DING ,  Marie-Helene LARRAUFIE ,  Deborah ROTHMAN ,  Nik SAVAGE ,  Shaowen WANG

IPC: C07D498/18 ,  A61K31/436

CPC classification number: C07D498/18 ,  A61K31/436 ,  A61K31/453 ,  A61K45/06 ,  C07D498/08

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.

公开(公告)号：US20220315582A1

公开(公告)日：2022-10-06

申请号：US16973836

申请日：2020-07-31

Applicant: Novartis AG

Inventor： Chris ADAIR ,  Tracy CHEN ,  Jian DING ,  Christy FRYER ,  Yuko ISOME ,  Marie-Helene LARRAUFIE ,  Katsumasa NAKAJIMA ,  Nik SAVAGE ,  Ariel Sterling TWOMEY

IPC: C07D471/10 ,  A61P35/00

Abstract: The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

公开(公告)号：US20190194227A1

公开(公告)日：2019-06-27

申请号：US16286002

申请日：2019-02-26

Applicant: NOVARTIS AG

Inventor： Jian DING ,  Marie-Helene LARRAUFIE ,  Deborah ROTHMAN ,  Nik SAVAGE ,  Shaowen WANG

IPC: C07D498/18 ,  A61K31/453 ,  C07D498/08 ,  A61K31/436 ,  A61K45/06

CPC classification number: C07D498/18 ,  A61K31/436 ,  A61K31/453 ,  A61K45/06 ,  C07D498/08

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.