公开(公告)号：US11426375B2

公开(公告)日：2022-08-30

申请号：US16854355

申请日：2020-04-21

Applicant: NOVARTIS AG

Inventor： Yongshuai Chai ,  Sven Erik Godtfredsen ,  Mark Kagan ,  Yugang Liu ,  Mahavir Prashad ,  Zhaoyin Wang ,  Saijie Zhu

IPC: A61K31/235 ,  A61K31/24 ,  A61K31/41 ,  A61K31/197 ,  A61P9/00 ,  A61K31/405 ,  C07C229/36 ,  C07C233/47 ,  C07C279/14 ,  C07D209/08

Abstract: The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.

公开(公告)号：US20180344679A1

公开(公告)日：2018-12-06

申请号：US16006252

申请日：2018-06-12

Applicant: Novartis AG

Inventor： Lili Feng ,  Sven Erik Godtfredsen ,  Paul Allen Sutton ,  Mahavir Prashad ,  Michael J. Girgis ,  Bin Hu ,  Yugang Liu ,  Thomas J. Blacklock ,  Piotr Henryk Karpinski

IPC: A61K31/216 ,  C07D207/50 ,  C07D257/04 ,  C07C233/47 ,  A61K31/5415 ,  A61K31/41 ,  A61K31/4422 ,  A61K45/06

CPC classification number: A61K31/216 ,  A61K31/41 ,  A61K31/4422 ,  A61K31/5415 ,  A61K45/06 ,  A61K2300/00 ,  C07C233/47 ,  C07D207/50 ,  C07D257/04

Abstract: A method for treatment of a cardiovascular or renal condition or disease with a specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi.

公开(公告)号：US09802931B2

公开(公告)日：2017-10-31

申请号：US14997207

申请日：2016-01-15

Applicant: Novartis AG

Inventor： Wolfgang Marterer ,  Mahavir Prashad ,  Edwin Bernard Villhauer ,  Liladhar Murlidhar Waykole ,  James Anthony Vivelo ,  Bertrand Sutter ,  Jean-Claude Bianchi ,  Raeann Wu ,  Denis Har ,  Piotr H. Karpinski ,  Massimo Pignone ,  Doris Stingelin ,  Eckart Buerger

IPC: C07C55/08 ,  C07D453/02 ,  A61K9/20 ,  A61K31/194 ,  A61K31/439 ,  C07C55/10 ,  C07C57/145 ,  C07C57/15 ,  C07C51/41

CPC classification number: C07D453/02 ,  A61K9/2054 ,  A61K31/194 ,  A61K31/439 ,  A61K2300/00 ,  C07B2200/07 ,  C07B2200/13 ,  C07C51/412 ,  C07C55/08 ,  C07C55/10 ,  C07C57/145 ,  C07C57/15

Abstract: The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

公开(公告)号：US20160145253A1

公开(公告)日：2016-05-26

申请号：US14997207

申请日：2016-01-15

Applicant: Novartis AG

Inventor： Wolfgang Marterer ,  Mahavir Prashad ,  Edwin Bernard Villhauer ,  Liladhar Murlidhar Waykole ,  James Anthony Vivelo ,  Bertrand Sutter ,  Jean-Claude Bianchi ,  Raeann Wu ,  Denis Har ,  Piotr H. Karpinski ,  Massimo Pignone ,  Doris Stingelin ,  Eckart Buerger

IPC: C07D453/02 ,  C07C57/145 ,  C07C55/10 ,  C07C55/08 ,  C07C57/15 ,  C07C51/41

CPC classification number: C07D453/02 ,  A61K9/2054 ,  A61K31/194 ,  A61K31/439 ,  A61K2300/00 ,  C07B2200/07 ,  C07B2200/13 ,  C07C51/412 ,  C07C55/08 ,  C07C55/10 ,  C07C57/145 ,  C07C57/15

Abstract: The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

Abstract translation: 本发明涉及（R）-3-（6-（4-甲基苯基） - 吡啶-3-基氧基）-1-氮杂 - 双环[2.2.2]辛烷的盐，其制备方法或其前体， 包含它们的药物组合物以及它们作为药物的用途。

公开(公告)号：US10421755B2

公开(公告)日：2019-09-24

申请号：US15712279

申请日：2017-09-22

Applicant: Novartis AG

Inventor： Wolfgang Marterer ,  Mahavir Prashad ,  Edwin Bernard Villhauer ,  Liladhar Murlidhar Waykole ,  James Anthony Vivelo ,  Bertrand Sutter ,  Jean-Claude Bianchi ,  Raeann Wu ,  Denis Har ,  Piotr H. Karpinski ,  Massimo Pignone ,  Doris Stingelin ,  Eckart Buerger

IPC: C07D453/02 ,  A61K9/20 ,  A61K31/194 ,  A61K31/439 ,  C07C55/08 ,  C07C55/10 ,  C07C57/145 ,  C07C57/15 ,  C07C51/41

Abstract: The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

公开(公告)号：US20180009801A1

公开(公告)日：2018-01-11

申请号：US15712279

申请日：2017-09-22

Applicant: Novartis AG

Inventor： Wolfgang Marterer ,  Mahavir Prashad ,  Edwin Bernard Villhauer ,  Liladhar Murlidhar Waykole ,  James Anthony Vivelo ,  Bertrand Sutter ,  Jean-Claude Bianchi ,  Raeann Wu ,  Denis Har ,  Piotr H. Karpinski ,  Massimo Pignone ,  Doris Stingelin ,  Eckart Buerger

IPC: C07D453/02 ,  A61K31/439 ,  C07C55/10 ,  C07C57/145 ,  C07C51/41 ,  A61K9/20 ,  C07C57/15 ,  A61K31/194 ,  C07C55/08

Abstract: The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

公开(公告)号：US10668035B2

公开(公告)日：2020-06-02

申请号：US16388221

申请日：2019-04-18

Applicant: NOVARTIS AG

Inventor： Yongshuai Chai ,  Sven Erik Godtfredsen ,  Mark Kagan ,  Yugang Liu ,  Mahavir Prashad ,  Zhaoyin Wang ,  Saijie Zhu

IPC: C07D205/00 ,  A61K31/235 ,  A61K31/197 ,  A61P9/00 ,  C07C229/36 ,  A61K31/405 ,  C07D209/08 ,  A61K31/41 ,  C07C279/14 ,  C07C233/47

Abstract: The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.